Diabetes is a disease that is present worldwide and which is associated with a large number of potential complications including chronic kidney disease (CKD). Several factors have been implicated in the development of the latter, including advanced glycation end-products (AGEs), which are formed from the interaction between sugar and proteins. AGE toxicity may be triggered via different mechani...
Oxidative stress plays an important role in diabetic nephropathy pathogenesis. Rosmarinic acid, a plant phenolic compound, was first used as an antioxidant agent for inhibition of diabetic nephropathy.
Material and Methods
Forty male rats were uninephrectomized from the left flank.The rats were divided in four groups randomly; group one as control, group two diabetic untreatment...
Diabetes mellitus is the most common cause of chronic
renal disorders and end-stage kidney disease in developed countries. It is the
major cause of dialysis and transplantation. Failure in renal function causes
wide disorders in the body. Diabetes results in wide range of alterations in
the renal tissue. It is believed that early
histological changes in diabetic nephropathy are detectabl...
Janet K. Snell-Bergeon,
Michel B. Chonchol,
Richard J. Johnson,
David M. Maahs,
Diabetic nephropathy (DN) is a major cause of mortality in type 1 diabetes. Reduced insulin sensitivity is a well-documented component of type 1 diabetes. We hypothesized that baseline insulin sensitivity would predict development of DN over 6 years.
RESEARCH DESIGN AND METHODS
We assessed the relationship between insulin sensitivity at baseline and development of early phenotypes o...
:Arquivos brasileiros de endocrinologia e metabologia2010
Mariana P Carpena,
Dimitris V Rados,
Denise A Sortica,
Bianca M de Souza,
André Fernandes Reis,
Luis Henrique Canani,
The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can deve...
Diabetes is the disorder most often linked with development of end-stage renal disease (ESRD) in the USA, Europe, South America, Japan, India, and Africa. Kidney disease is as likely to develop in long-duration non-insulin dependent diabetes (type 2) as in insulin-dependent diabetes mellitus (type 1). Nephropathy in diabetes — if suboptimally managed — follows a predictable course starting with...
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, plays a key role in both physiologic and pathologic events, including wound healing, cancer, and diabetes. Neovascularization has been implicated in the genesis of diverse diabetic complications such as retinopathy, impaired wound healing, neuropathy, and, most recently, diabetic nephropathy. Diabetic nephropathy is...
Hypothesis Implication for health policy/practice/research/medical education: The combination of metformin and ginger extract may be more effective for the control of diabetes and may have additive protective efficacy on diabetic nephropathy. N ephropathy of the diabetes is one of the most important complications of this illness. Recently, much attention has been made toward the possible kidney...
The clinical manifestations of diabetic nephropathy, proteinuria, increased blood pressure, and decreased glomerular filtration rate, are similar in type 1 and type 2 diabetes; however, the renal lesions underlying renal dysfunction in the 2 conditions may differ. Indeed, although tubular, interstitial, and arteriolar lesions are ultimately present in type 1 diabetes, as the disease progresses,...
Oxidative stress has crucial role in pathogenesis of diabetic nephropathy (DN). Despite satisfactory results from antioxidant therapy in rodent, antioxidant therapy showed conflicting results in combat with DN in diabetic patients.
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