نتایج جستجو برای Diabetic nephropathy

تعداد نتایج: 62374  

2012
Maïté Daroux,

Diabetes is a disease that is present worldwide and which is associated with a large number of potential complications including chronic kidney disease (CKD). Several factors have been implicated in the development of the latter, including advanced glycation end-products (AGEs), which are formed from the interaction between sugar and proteins. AGE toxicity may be triggered via different mechani...

Ahmad Tamjidipoor, Alireza Khalatbari, Hasan Ahmadvand, Majid Tavafi,

Objective(s) Oxidative stress plays an important role in diabetic nephropathy pathogenesis. Rosmarinic acid, a plant phenolic compound, was first used as an antioxidant agent for inhibition of diabetic nephropathy. Material and Methods Forty male rats were uninephrectomized from the left flank.The rats were divided in four groups randomly; group one as control, group two diabetic untreatment...

  Diabetes mellitus is the most common cause of chronic renal disorders and end-stage kidney disease in developed countries. It is the major cause of dialysis and transplantation. Failure in renal function causes wide disorders in the body. Diabetes results in wide range of alterations in the renal tissue. It is believed that early histological changes in diabetic nephropathy are detectabl...

2013
Petter Bjornstad, Janet K. Snell-Bergeon, Marian Rewers, Diana Jalal, Michel B. Chonchol, Richard J. Johnson, David M. Maahs,

OBJECTIVE Diabetic nephropathy (DN) is a major cause of mortality in type 1 diabetes. Reduced insulin sensitivity is a well-documented component of type 1 diabetes. We hypothesized that baseline insulin sensitivity would predict development of DN over 6 years. RESEARCH DESIGN AND METHODS We assessed the relationship between insulin sensitivity at baseline and development of early phenotypes o...

Journal: :Arquivos brasileiros de endocrinologia e metabologia 2010
Mariana P Carpena, Dimitris V Rados, Denise A Sortica, Bianca M de Souza, André Fernandes Reis, Luis Henrique Canani, Daisy Crispim,

The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can deve...

2001
Eli A. Friedman,

Diabetes is the disorder most often linked with development of end-stage renal disease (ESRD) in the USA, Europe, South America, Japan, India, and Africa. Kidney disease is as likely to develop in long-duration non-insulin dependent diabetes (type 2) as in insulin-dependent diabetes mellitus (type 1). Nephropathy in diabetes — if suboptimally managed — follows a predictable course starting with...

Journal: :Seminars in nephrology 2007
Roy Zent, Ambra Pozzi,

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, plays a key role in both physiologic and pathologic events, including wound healing, cancer, and diabetes. Neovascularization has been implicated in the genesis of diverse diabetic complications such as retinopathy, impaired wound healing, neuropathy, and, most recently, diabetic nephropathy. Diabetic nephropathy is...

2013
Mahmoud Rafieian-Kopaei, Hamid Nasri,

Hypothesis Implication for health policy/practice/research/medical education: The combination of metformin and ginger extract may be more effective for the control of diabetes and may have additive protective efficacy on diabetic nephropathy. N ephropathy of the diabetes is one of the most important complications of this illness. Recently, much attention has been made toward the possible kidney...

Journal: :Seminars in nephrology 2007
Paola Fioretto, Michael Mauer,

The clinical manifestations of diabetic nephropathy, proteinuria, increased blood pressure, and decreased glomerular filtration rate, are similar in type 1 and type 2 diabetes; however, the renal lesions underlying renal dysfunction in the 2 conditions may differ. Indeed, although tubular, interstitial, and arteriolar lesions are ultimately present in type 1 diabetes, as the disease progresses,...

Journal: :Journal of nephropathology 2013
Majid Tavafi,

CONTEXT Oxidative stress has crucial role in pathogenesis of diabetic nephropathy (DN). Despite satisfactory results from antioxidant therapy in rodent, antioxidant therapy showed conflicting results in combat with DN in diabetic patients. EVIDENCE ACQUISITIONS Directory of Open Access Journals (DOAJ), Google Scholar,Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. RESULTS...

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