objective(s): stem cell differentiation into different cell lineages depends upon several factors, cell cycle control elements and intracellular signaling elements, including p15ink4b and p16ink4a genes. epigenetics may be regarded as a control mechanism which is affected by these factors with respect to their promoter structure.   materials and methods: the cd34 + cord blood stem cells were pu...

the capacity of mesenchymal stem cells (mscs) to differentiate among skeletal cell lineages and to undergo extensive proliferation in vitro renders them an appropriate source for cell-replacement therapy to heal defects of bone and cartilage tissue.it is argued that in bone and cartilage defects, mscs would better be transplanted as fully-differentiated cells otherwise they may produce non-spec...

Objective(s): The stimulation of neural stem cells (NSCs) differentiation into neurons has attracted great attention in management of neurodegenerative disease and traumatic brain injury. It has been reported that selegiline could enhance the morphologic differentiation of embryonic stem cells. Therefore this study aimed to investigate the effects of selegiline on NSCs differentiation with focu...

Background: The role of mesenchymal stem cell in cellular therapy is the subject of interest for many researchers. The differentiation potential of MSCs and abilities in modulations of the recipient’s immune system makes them important cells in tissue regenerative studies. MSCs by releasing the proinflammatory cytokines play important role in immunomodulatory systems; however the signaling path...

Mucinous carcinoma of the breast is a well-differentiated type of adenocarcinoma accounting for 2-5% of all breast cancers. Pure mucinous carcinoma of the breast has a favorable prognosis, usually seen in post-menopausal women. Neuroendocrine differentiation has been described in both in-situ and infiltrating breast cancers .Mucinous carcinomas of the breast appear to have the greatest associat...

Objective(s): Naringin has been reported to regulate bone metabolism. However, its effect on osteogenesis remains unclear. The aim was to investigate the effect of naringin on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through the activation of the ERK signaling pathway in osteogenic differentiation. Materials and Methods: Annexin V-FITC assay and MTT assay ...

The Lie derivation of multivector fields along multivector fields has been introduced by Schouten (see cite{Sc, S}), and studdied for example in cite{M} and cite{I}. In the present paper we define the Lie derivation of differential forms along multivector fields, and we extend this concept to covariant derivation on tangent bundles and vector bundles, and find natural relations between them and...

to evaluate the genetic variations in eleven fennel populations in iran, 55 accessions were analyzed by srap markers. twelve primer combinations produced 171 polymorphic bands. the cumulative dendrogram delineated fennel accessions into five major groups in accordance to the geographical regions from which the populations were originated. about 43.57% of total genetic variation was detected amo...

background: several influential factors such as transcription factors and intracellular signaling components are involved in differentiation of stem cells into a specific lineage. p15 and p16 proteins are among these factors. accumulating evidences has introduced the epigenetic as a master regulator of these factors during lineage specification. the main objective of this study is to determine ...