OBJECTIVES Thiazide diuretics are one of the first choice antihypertensives but not optimally utilised because of concerns regarding their adverse effects on glucose metabolism. The Diuretics In the Management of Essential hypertension (DIME) study was designed, for the first time, to assess the risk for type 2 diabetes mellitus in patients with essential hypertension during antihypertensive tr...

Abstract Purpose The aim of this systematic literature review was to obtain an overview when administer the diuretics in relation radiopharmaceutical during a diuresis renography. Methods A search performed three different databases (Embase, PubMed/Medline and Cochrane Library) together with information specialist. question was: should be administered renography? Studies adults were included gu...

Lowering blood pressure using thiazide-like diuretics, including chlorthalidone and hydrochlorothiazide, has been proven to be effective in clinical studies. However, the mechanisms by which thiazide-like diuretics lower blood pressure are still poorly understood. To evaluate whether thiazide-like diuretics cause calcium desensitization in smooth muscle cells, we measured their effects on agoni...