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T HE USE OF DIURETICS was revolutionized some 6 or 7 years ago by the introduction of chlorothiazide, the first satisfactorily effective orally administered diuretic. The fact that at least two far more potent diuretics, also effective on oral administration, are probably close to release for general use' 2 makes it appropriate to take stock of the present situation and to consider the prospect...

Authors: Ferreira R. The use of diuretics (and beta-blockers) to treat hypertension has known a dramatic decline since the early 1980’s through to the early 1990s with the introduction of ACE-inhibitors and calcium channel blockers. However, thiazide diuretics are still a first line option to treat arterial hypertension, due to their efficacy and cost-effectiveness profile. We have presented ma...

Diuretics are commonly used to control edema across various clinical fields. Diuretics inhibit sodium reabsorption in specific renal tubules, resulting in increased urinary sodium and water excretion. Loop diuretics are the most potent diuretics. In this article, we review five important aspects of loop diuretics, in particular furosemide, which must be considered when prescribing this medicine...

Hypertension is highly prevalent in Canada, affecting more than 20% of all adults. Thiazide diuretics have been shown in numerous studies to be effective agents for controlling blood pressure and reducing cardiovascular disease and death in hypertensive patients. Thiazide diuretics are recommended as initial first line therapy for uncomplicated hypertension in the 2003 Canadian Hypertension rec...

Many patients with edema of congestive cardiac failure, nephrosis, and cirrhosis become refractory to all diuretic therapy. Theoretically, the use ia adequate dosage of osmotic diuretics whose action is dependent upon physical factors should augment sodium, chloride, and water excretion from whatever level exists prior to their use. In refractory edema, the effect of other diuretics (via altera...

Diuretics are pharmacologic agents that increase the excretion of water and electrolytes. They are primarily used in states of inappropriate salt and water retention. Such states can be the consequence of congestive heart failure (CHF), renal diseases, and liver disease. Diuretics are also used in various conditions not evidently associated with salt retention. Such conditions include oliguric ...

A potassium loading study was performed in acutely nephrectomized rats to determine the extrarenal effects of diuretics on potassium tolerance. Four diuretics were evaluated: hydrochlorothiazide, furosemide, bumetanide, and spironolactone. Following an intravenous potassium load (0.17 mEq/100 g over one hour), plasma potassium concentration rose by 2.69 +/- 0.26 to 3.67 +/- 0.20 mEq/L in all gr...

OBJECTIVE To examine the association of myocardial infarction and stroke incidence with several commonly used two drug antihypertensive treatment regimens. Design Population based case-control study. Setting Group Health Cooperative, Seattle, WA, USA. PARTICIPANTS Cases (n=353) were aged 30-79 years, had pharmacologically treated hypertension, and were diagnosed with a first fatal or non-fata...

OBJECTIVE: To evaluate the impact of diuretics and dopamine for both the prevention and treatment of renal dysfunction in the acute care setting. STUDY IDENTIFICATION AND SELECTION: Studies were identified via MEDLINE, and through bibliographies of primary and review articles. Articles were then screened by the author for studies addressing the use of diuretics or dopamine in the prevention and...