Estrogen-related receptors (ERR), ERR alpha (ERRa) and ERR gamma (ERRg), are orphan nuclear receptors implicated in breast cancer that function similarly in the regulation of oxidative metabolism genes. Paradoxically, in clinical studies, high levels of ERRa are associated with poor outcomes whereas high levels of ERRg are associated with a favorable course. Recent studies suggest that ERRa may...

Objective(s): Since bisphenol A (BPA) induces bone loss and phytoestrogens enhance the osteoblastogenesis by binding to the non-classical and classical oestrogen receptors, respectively, the present study was aimed to observe the osteoprotective effect of phytoestrogens on BPA-induced osteoblasts in hFOB 1.19 cells.Materials and Methods:...

Steroid receptor coactivators* SRC-1/NCOA1; SRC-2/NCOA2; (GRIP1, TIF2); SRC-3/NCOA3; (AIB1, ACTR, TRAM-1, RAC3) SRC-1 AR, COUP-TFI, CAR, ERα, ERβ, ERRg, FXRα, GR, HNF4α, PPARα, PPARg, PXR, PR, RORβ, RARα, RARβ, RXRα, RXRβ, SF-1, TRα, TRβ, EAR Coactivators for the NR superfamily and other transcription factors; roles in reproductive development and metabolism. Domains: PAS/ bHLH, acetyltransfera...

Consider the inhomogeneous Erd\H{o}s-R\'enyi random graph (ERRG) on $n$ vertices for which each pair $i,j\in\{1,\ldots,n\}$, $i\neq j$ is connected independently by an edge with probability $r_n(\frac{i-1}{n},\frac{j-1}{n})$, where $(r_n)_{n\in\mathbb{N}}$ a sequence of graphons converging to reference graphon $r$. As generalization celebrated LDP ERRGs Chatterjee and Varadhan (2010), Dhara Sen...

The statistics of strongly interacting, ultracold Rydberg gases are governed by the interplay two factors: geometrical restrictions induced blockade effects, and quantum mechanical effects. To shed light on their relative roles in gases, we compare three models this paper: a model describing excitation dynamics within gas, Random Sequential Adsorption (RSA) process Geometric Graph (RGG), RSA De...

BACKGROUND Impaired bioenergetics is a prominent feature of the failing heart, but the underlying metabolic perturbations are poorly understood. METHODS AND RESULTS We compared metabolomic, gene transcript, and protein data from 6 paired samples of failing human left ventricular tissue obtained during left ventricular assist device insertion (heart failure samples) and at heart transplant (po...

Insulin is the major hormone that regulates hepatic glucose metabolism by repressing gluconeogenic enzyme-encoding genes, and the counteracting glucagon/protein kinase (PKA)–inducible coactivating peroxisome proliferator– activated receptor g coactivator-1a (PGC-1a) signaling pathway is also well characterized in hepatic glucose metabolism (1–3). Until now, however, the regulation of the insuli...

We previously showed that (a) estrogen-related receptor A1 (ERRA1) down-modulates estrogen receptor (ER)–stimulated transcription in low ErbB2–expressing MCF-7 mammary carcinoma cells, and (b) ERRA and ErbB2 mRNA levels positively correlate in clinical breast tumors. We show here that ERRA1 represses ERA-mediated activation in MCF-7 cells because it failed to recruit the coactivator glucocortic...