نتایج جستجو برای Elevated plus maze

تعداد نتایج: 223092  

2008
Munekazu Komada, Keizo Takao, Tsuyoshi Miyakawa,

Although the mouse genome is now completely sequenced, the functions of most of the genes expressed in the brain are not known. The influence of a given gene on a specific behavior can be determined by behavioral analysis of mutant mice. If a target gene is expressed in the brain, behavioral phenotype of the mutant mice could elucidate the genetic mechanism of normal behaviors. The elevated plu...

Minoo Mahmoodi, Nasrin Hashemi-Firouzi, Siamak Shahidi,

Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2000
C M Padovan, F S Guimarães,

Rodents submitted to restraint stress show decreased activity in an elevated plus-maze (EPM) 24 h later. The objective of the present study was to determine if a certain amount of time is needed after stress for the development of these changes. We also wanted to verify if behavioral tolerance of repeated daily restraint would be detectable in this model. Male Wistar rats were restrained for 2 ...

Alireza Komaki, Nasrin Hashemi-Firouzi, Shiva Shojaie, Siamak Shahidi, Somayeh Heidari, Zobin Souri,

Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat. The EPM is o...

ارضی, اردشیر, خدایار, محمد جواد, زرین دست, محمدرضا, سرهرودی, شادی,

زمینه و هدف کانابینوئیدها که اجزای فعال ماری‌جوانا می‌باشند و اثراتی شبیه به اوپیوئیدها دارند. به‌علاوه میان این دو سیستم تداخلات عملکردی نیز وجود دارد. هدف این مطالعه بررسی اثر سیستم کانابینوئیدی بر اضطراب در آمیگدال مرکزی، و تداخل آن با سیستم اوپیوئیدی است. روش بررسی در مطالعه حاضر، اثر تزریق داخل صفاقی داروهای اوپیوئیدی بر پاسخ حاصل از تزریق داخل آمیگدال عوامل کانابینوئیدی در موش‌های صحرایی،...

2012
Dinesh Dhingra, Varun Kumar,

The present study was designed to evaluate the effect of palmatine on memory of Swiss young male albino mice. Palmatine (0.1, 0.5, 1 mg/kg, i.p.) and physostigmine (0.1 mg/kg, i.p.) per se were administered for 10 successive days to separate groups of mice. Effect of drugs on learning and memory of mice was evaluated using elevated plus maze and Morris water maze. Brain acetylcholinesterase act...

Amit Kumar Ray, Rakesh Kumar Sinha,

This paper presents the effect of high environmental heat on behavior of the male Charles Foster rats. Eighty rats were divided into three groups, subjected to (i) acute heat stress (ii) chronic heat stress and (iii) handling control group. Animals were exposed to the hot environment in a biological oxygen demand incubator at 38 ± 1ºC (relative humidity 45-50%) for four hours of continuous sing...

Journal: :jentashapir journal of health research 0
yaghoob farbood department of physiol..., seyyed mohammad taghi mansouri depart..., seyyed mostafa ahmadian department of..., seyyad ali mard department of physiol..., alireza sarkaki department of physiol...,

conclusions acute and chronic administration of ellagic acid had anxiolytic property. also, the most effective dose of ellagic acid was 30 mg/kg. pretreatment with flumazenil reversed the beneficial effect of ellagic acid and diazepam on anxiety. it is likely that the anxiolytic effect of ellagic acid is largely mediated by activation of gabaa receptor. results acute and chronic application of ...

Jamal Shams, Soroush Mazloumi, Tajmah Mombeini,

Background and Objective: The medicinal plant Origanum vulgare. subsp. vulgare in the Lamiaceae family has been widely used by Iranian people for the treatment of respiratory, gastrointestinal and neurologic disorders. The present study was carried out to evaluate possible anxiolytic effects of aqueous extract of O. vulgare leaves and the flowering branches in rats.Materials and Methods: Anxiol...

Fereshte Manafi, Leila Etemadi, Masoud Fereidoni, Shahrbanoo Oryan, Vaezi Gholamhasan,

Based on the extensive application of Peganum harmala (P.h) seeds in the Asian traditional medicine, we tried to investigate its possible anxiety effect. Method: The effect of P.h. extract inhalation was evaluated in adult male rats using elevated plus-maze apparatus. The humidity of prepared ethanol extract was 37%. Animals in different groups (n=6) received 2, 4, 6, 12 or 18 gr/ml doses of...

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