This study investigated the effects of perinatal genistein (GEN) exposure on the central nervous system of rat offspring. Pregnant dams orally received GEN (1 or 10 mg/kg/day) or vehicle (1 ml/kg/day) from gestation day 10 to postnatal day 14. In order to assess the effects of GEN on rat offspring, we used a battery of behavioral tests, including the open-field, elevated plus-maze, MAZE and ste...

Diabetes mellitus is one of the most common causes of neuropathy. Although antioxidant and antidiabetic effects of the aqueous extract of purslane (Portulaca oleracea) (AEOP) have been demonstrated before by other researchers, we did not find any study that assessed the psychobiological effects of AEOP in diabetes induced animals. Thirty ovariectomized (OVX) female Wistar rats were randomly div...

Background and Objective: Crassocephalum bauchiense Hutch is a species of flowering plant from the Asteraceae family. It’s used in traditional medicine for treatment brain disorders including epilepsy, depression anxiety. This study evaluated anxiolytic effects aqueous extract its possible mechanism action. Materials Methods: The (25, 50, 100 200 mg/kg) were administered orally to mice one hour...

The petroleum ether (PE), chloroform (CH), ethanol (ETH) and water extracts of E. arvense stems were evaluated for anti-anxiety activity in mice using elevated plus maze model. Ketamine induced hypnosis and actophotometer was used to evaluate sedative effect with various extracts in mice. The results were compared with standard drug diazepam. The ethanolic extract of E. arvense (50 and 100 mg/k...

Because zinc deficiency induces depression and anxiety-like behavior in rodents, we examined the effects of zinc administration in several tests by measuring anxiolytic activity in mice and rats. We now report that zinc significantly increased the number of entries into the open arms in the elevated plus maze in rats. Moreover, zinc treatment significantly increased the number of punished cross...

The present study was carried out to investigate the anxiolytic activity of Ipomoea aquatica leaves. The shade dried leaves were extracted successively with petroleum ether and methanol: acetone (MAE-IA). The total flavonoids contents were determined as 200 mg/kg of dried plant material. The anxiolytic activity of MAE-IA was evaluated using elevated plus maze, light: dark apparatus, hole board ...