Behavioral characteristics of the animal models and humans are impaired in chronic stress. The present study aimed to evaluate and compare the protective effects of sertraline and curcumin on stress-induced learning and memory impairment, anxiety and anhedonia in rats. Male rats were divided into seven groups: stress+water, stress+olive oil, stress+curcumin (100 mg/kg/day), stress+sertraline (1...

The present study was undertaken to evaluate the anxiolytic activity of methanolic extract of Sapindus mukorossi Gaertn.(Sapindaceae). The anxiolytic activity was evaluated by Elevated plus maze, Y-maze, Hole-board, Actophotometer, and Marble-burying behavior models. The efficacy of the extract (200 and 400 mg/kg) was compared with the standard anxiolytic drugs Diazepam (2 mg/kg) and Fluoxetine...

Objective: The study was undertaken to compare the effect of ondansetron, granisetron and alprazolam on anxiety in rats. Materials and Methods: Elevated plus maze and Open field test were used to compare the effect of drugs on anxiety in rats. Six groups of rats were treated with 2% gum acacia orally, alprazolam 0.08mg/kg body weight of the rat orally, ondansetron (0.01mg/kg, 1mg/kg intraperito...

To investigate the behavioral effects of different vehicles microinjected into the dorsal periaqueductal grey (DPAG) of male Wistar rats, weighing 200-250 g, tested in the elevated plus maze, animals were implanted with cannulas aimed at this structure. One week after surgery the animals received microinjections into the DPAG of 0.9% (w/v) saline, 10% (v/v) dimethyl sulfoxide (DMSO), 2% (v/v) T...

Systematic observations of the defensive behavior of wild rodents have greatly informed the experimental study of anxiety and its neural substrates in laboratory animals. However, as the former work has been almost exclusively carried out in rats, few data are available concerning the reactivity of wild mice to standardized tests of anxiety-related behavior. In the present experiments, we emplo...

some studies suggested that glucocorticoid receptors activities can modulate fear and anxiety. according to that, the purpose of this research is to assess the modulatory effect of glucocorticoid receptors on the anxiety assessed in plus maze. in this research mice with medium weight of 20-25 g were used. the male and female animals separately sorted in two groups as control and experiment rand...

To study anxiolytic and antidepressant effect of Astaxanthin as an adjuvant to standard drug.In this study, to investigate the effects of astaxanthin on anxiety and depression,we performed some behavioural trials including elevated plus maze test, hole-board test, forced swim test, and tail suspension test.Astaxanthin ( 3 mg/kg/day for 15 days, orally) significantly increased the time spent in ...

Female hooded-Lister rats received either sub-chronic phencyclidine (PCP) (2 mg/kg, n=20) or vehicle (1 ml/kg, n=20) i.p. twice daily for seven days, followed by a sevenday washout period. Rats were challenged with acute PCP or vehicle and tested for locomotor activity to ensure hyperactivity was observed in the sub-chronic PCP treated rats. Rats were then tested on the elevated plus maze and i...