× خانه ژورنال ها پست ها ثبت نام ورود

نتایج جستجو برای Ethanol toxicity

تعداد نتایج: 159512  
Journal: :Acta poloniae pharmaceutica 2010
Anna Długosz, Anna Pruss, Jadwiga Lembas-Bogaczyk,

2018
Luisa M Vera, Carolina Bello, Juan F Paredes, Greta Carmona-Antoñanzas, Francisco J Sánchez-Vázquez,

Ethanol is one of the most commonly abused drugs and consequently its toxic and psychoactive effect has been widely investigated, although little is known about the time-dependent effects of this drug. In the present research zebrafish was used to assess daily rhythms in ethanol toxicity and behavioural effects, as well as the temporal pattern of expression of key genes involved in ethanol deto...

2012
Metoda Lipnik-Štangelj,

Ethanol consumption has for a long time been associated with brain damage. Experimental studies and necropsy examinations of chronic alcoholics have shown a variety of structural and functional alterations in the neurons as well as in the glial cells. Such alterations are seen also in children with the alcoholic foetal syndrome. Ethanol is known to be a teratogen. Its abusage can result as dysf...

2013
Jie Zhao, Jia-Xi Zhao, Ya-Jun Xu,

The objective of this study was to assess whether nucleotides supplementation in vitro could suppress ethanol-induced developmental toxicity in mouse. The models of whole embryo culture (WEC) and midbrain (MB) cell micromass culture were used in this study. In WEC system, exposure to 4.0 mg/mL ethanol for 48 h yielded various developmental malformations of the mice embryos. Nucleotides suppleme...

2012
Brigitte Gonthier, Nathalie Allibe, Cécile Cottet-Rousselle, Frédéric Lamarche, Laurence Nuiry, Luc Barret,

Aims. 3,5,4'-Trihydroxy-trans-stilbene, a natural polyphenolic compound present in wine and grapes and better known as resveratrol, has free radical scavenging properties and is a potent protector against oxidative stress induced by alcohol metabolism. Today, the mechanism by which ethanol exerts its toxicity is still not well understood, but it is generally considered that free radical generat...

Alireza Timcheh Hariri, Elahe Taghiabadi, Hamed Pourbakhsh, Hossein Hosseinzadeh, Khalil Abnous, Sayed Masoud Hosseini,

Objective(s):This study was planned to appraise the protective effect of Nigella sativa fixed oil (NSO) against subchronic ethanol induced toxicity in rats. Materials and Methods: Studies were carried out on six groups of six animals each, including control (normal saline, gavage), ethanol (3 g/kg/day, gavage), NSO (0.125, 0.25 and 0.5 ml/Kg/day, IP) plus ethanol and NSO (0.5 ml/Kg/day, IP) gro...

Objective: The plantCassia fistula L. (Caesalpiniaceae) is traditionally used to treat heart diseases, abdominal pain and fever. The present study was aimed to investigate the toxic effects acute and sub-acute administration of ethanol extract of C. fistula fruit (CFE) in male Wistar rats. Materials and Methods: In acute toxicity, the effects of a single oral dose (1000, 3000 and 5000 mg/kg) of...

Ali Reza Timcheh Hariri, Elaheh Taghiabadi, Hamed Pourbakhsh, Hossein Hosseinzadeh, Khalil Abnous, Seyed Masoud Hosseini,

Background: In this study, the protective effect of thymoquinone (TQ) and Nigella sativa seeds oil (NSO) was evaluated against oxidative damages induced by ethanol in rats. Methods: Animals were treated with ethanol 40% daily by gavages once a day for 4 weeks. NSO and TQ were injected intraperitoneal once a day for 4 weeks. The histopathological examination of liver, kidney, brain and heart was...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2002
Ping Zhao, John T Slattery,

Chronic ethanol consumption potentiates acetaminophen (APAP) hepatotoxicity through enhanced NAPQI formation via CYP2E1 induction and selective depletion of mitochondrial glutathione. Because the prevalence of the interaction is extremely low given the use of APAP and the incidence of alcohol abuse, we studied the effects of ethanol dose and ethanol withdrawal on selective mitochondrial glutath...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Michael F Wilkemeyer, Shao-yu Chen, Carrie E Menkari, Douglas E Brenneman, Kathleen K Sulik, Michael E Charness,

NAPVSIPQ (NAP), an active fragment of the glial-derived activity-dependent neuroprotective protein, is protective at femtomolar concentrations against a wide array of neural insults and prevents ethanol-induced fetal wastage and growth retardation in mice. NAP also antagonizes ethanol inhibition of L1-mediated cell adhesion (ethanol antagonism). We performed an Ala scanning substitution of NAP ...