An AmpC-type beta-lactamase conferring high-level resistance to expanded-spectrum cephalosporins and monobactams was characterized from an Acinetobacter baumannii clinical isolate. This class C beta-lactamase (named ADC-33) possessed a Pro210Arg substitution together with a duplication of an Ala residue at position 215 (inside the Omega-loop) compared to a reference AmpC cephalosporinase from A...

OBJECTIVE To compare the in vitro efficacy of meropenem, colistin and tigecycline against extended spectrum Betalactamase producing Gram negative bacilli by minimal inhibitory concentration. STUDY DESIGN Cross-sectional descriptive study. PLACE AND DURATION OF STUDY Department of Microbiology, Army Medical College, National University of Sciences and Technology, Rawalpindi, from June to Dec...

According to the WHO global report, ESBL (Extended-Spectrum Beta-Lactamase)-producing microorganisms is most common cause of urinary tract infection; hospital-acquired infection as well a foodborne infection. These include Escherichia coli, Salmonella, Shigella and Vibrio cholera. The carbapenems which doripenem, ertapenem, imipenem meropenem are known choice medication for life-threatening inf...

conclusions the high prevalence of quinolone resistance genes, which indicates antibiotic resistance, in the imam reza hospital of mashhad is a major concern. hence, the antibiotics prescription policy should be revised, and infection control measures should be improved. results eighty-six (43%) isolates were ciprofloxacin-resistant. the pct identified 85 (42.5%) of 200 e. coli isolates as esbl...