نتایج جستجو برای: Extended-spectrum beta-lactamase
تعداد نتایج: 613447 فیلتر نتایج به سال:
Two clinical isolates of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem. Both were missing outer membrane proteins that serve as channels for antibiotic entry. The role of beta-lactamase in resistance was investigated by eliminating the original ESBL and introducing plasmids encoding various ESBLs and AmpC beta...
INTRODUCTION The rising prevalence of extended-spectrum beta-lactamases in gram-negative bacillary pathogens is an important clinical problem resulting from the extensive use of broad-spectrum antibiotics. The emergence of the extended-spectrum beta-lactamases increases the possibility that traditional, empiric antimicrobial regimens may be ineffective. The aims of this study are: to determine ...
There has been greater interest in developing additional antimicrobial agents due to the increasing health care costs and resistance resulting from bacterial pathogens to currently available treatment options. Gram-negative organisms including Enterobacteriaceae and Pseudomonas aeruginosa are some of the most concerning threats due to their resistance mechanisms: extended-spectrum beta-lactamas...
Resistance to cephalosporins in Haemophilus influenzae is usually caused by characteristic alterations in penicillin-binding protein 3 (PBP3), encoded by the ftsI gene. Resistance to extended-spectrum cephalosporins is associated with high-level PBP3-mediated resistance (high-rPBP3), defined by the second stage S385T substitution in addition to a first stage substitution (R517H or N526K). The t...
Background and purpose: Extended Spectrum Beta Lactamases (ESBLs) are one of the most important health care issues all over the world. Uropathogenesis are responsible for life threatening infections in children. In this study we aimed at investigating the epidemiology of CTX, TEM and VEB genes in pediatric UTI. Materials and methods: Urine samples were collected during six months in Sari Bou...
The resistance mechanisms of b-lactam antimicrobials in clinical isolates of Acinetobacter baumannii
BACKGROUND Despite increasing importance of Acinetobacter baumannii in nosocomial infections and rapid development of multi-antimicrobial resistance in this strain, the resistance mechanisms of beta-lactam antimicrobials in A. baumannii were not clearly defined. In order to observe the resistance mechanisms against beta-lactams and carbapenem, we characterized the production of beta-lactamases ...
Background: CTX-M-type extended-spectrum β-lactamases (ESBLs) are the most prevalent ESBLs in bacterial members of Enterobacteriaceae family including Klebsiella pneumoniae. The global spread of CTX-M-producing K. pneumoniae is a major concern in most countries including Iran. The aim of this meta-analysis was to determine the relative frequency (RF) of blaCTX-M gene among ESBLs-producing K. pn...
Background & Aim: clinical cases especially from hospitalized patients. Recently multiple drug resistant isolated from clinical cases. Resistances were seen against drugs belonging to different antibiotic families. In thissurvey, drug resistance in clinical isolates was studied with special reference to extended spectrum betalactamases.Escherichia coli is one of the most important and prevalent...
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