objective: the aim of this study was to test the effect of intravenous injection of mesenchymal stem cells (mscs) on doxorubicin (dox)-induced fibrosis in the heart. we investigated the mechanisms that possibly mediate this effect. materials and methods: in this experimental study, fibrosis in the myocardium of adult male wistar rats (weights 180-200 g, 9-10 weeks of age, total n=30) was create...

conclusions m30 levels were higher in cvhb patients compared to healthy controls. however, m30 levels were similar in the mild and moderate stages of fibrosis, so they did not indicate the severity of underlying fibrotic or inflammatory processes in cvhb patients. results the mean ages of patients and controls were 39.7 and 45.7 years, respectively, and 35% of the controls and 52% of the patien...

conclusions patients with chronic hepatitis c and with a ciscun ≤ 1 had a very low rate of cirrhosis while those with a ciscun = 4 had a high risk of cirrhosis. patients with ciscun = 2 or 3 had an intermediate rate of cirrhosis, and therefore needed to perform a liver biopsy to receive a reliable diagnosis. results we enrolled 249 patients who had complete laboratoristic data, and sufficient l...

a 64-year-old female with history of previous aortoiliac occlusion and aortoiliac bypass operation four months ago presented with dyspnea, ascites and leg edema. she has been suffering from bloody diarrhea since two weeks earlier. laboratory data showed important eosinophilia and stool examination was positive for strongyloides stercoralis. patient had clinical signs of heart failure. a cardiac...

many studies have been performed for treatment or prevention of pulmonary fibrosis. however, no effective treatment has been found yet. the aim of this study was to investigate the effect of grape seed extract on bleomycin-induced lung fibrosis in rat. hydroalcoholic extract of grape seed (vitis vinifera) was prepared using maceration method. nmri rats weighing 250-300 g were given single intra...

aim : in this study, to clarify the smad4blocking impact on fibrosis process, we investigated its down-regulation by shrna on activated human lx-2 cell, in vitro.   background : liver fibrosis is a critical consequence of chronic damage to the liver that can progress toward advanced diseases, liver cirrhosis and hepatocellular carcinoma (hcc).  different smad proteins play as major mediators in...

background serum apoptotic cytokeratine 18 neoepitope m30 (ck-18 m30) and matrix metalloproteinase 2 (mmp-2) have been popular markers for detecting liver fibrosis in recent years. ck-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apoptosis. mmp-2 plays an important role in tissue remodeling and repairing process...

pulmonary fibrosis is a progressive disease of the lungs, which leads to death in human. it has been suggested that transforming growth factor beta 1 (tgf-β1) together with oxidative stress play a central role in the pathogenesis of the ailment. the objective of this study was to evaluate the possible curative effects of black radish, raphanus sativus l . var niger (rsn) on bleomycine (blm) -in...

background: the renin-angiotensin system has an important role in hepatic inflammation and fibrosis. renin-angiotensin system blockade by angiotensinconverting enzyme (ace) inhibitors provides some protective effects against hepatic fibrogenesis. captopril as an ace inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (bdl) rats. object...

Nephrogenic systemic fibrosis (NSF), previously known as nephrogenic fibrosing dermopathy, is an emerging systemic fibrosing disorder that develops in the setting of renal insufficiency. Nephrogenic fibrosing dermopathy (NFD) is a fibrosing condition of the skin which shows an increased number of dendritic cells, fibroblasts and thickened collagen fibers resembling scleromyxedema. It is charact...