Background: Recent studies have shown that the course of cystic fibrosis in patients with this disease differs despite the same mutation in CFTR gene. We aimed to investigate the role of polymorphism in TNF α (-308) and TNF α (-863), and its effect on the phenotype of the patients with cystic fibrosis and progression of disease. Materials and Methods:...

cystic fibrosis (cf) is an inherited disease that primarily affects the lungs and the digestive system, however, it also affects a number of other organs and systems. more than 90% of mortality of  cf patients is due to lung complications.  healthy lungs are important for a long life for people with cf, we will discuss two important topics for maintaining respiratory health. chronic use of drug...

Abstract Background We evaluated the validity of some non-invasive scores and ultrasound findings to predict fibrosis steatosis in a cohort NAFLD patients who underwent liver biopsy. Ninety-seven were enrolled classified into NASH (66) simple groups (31) based on ROC curves constructed for Fibrosis-4 index (FIB4), aspartate aminotransferase platelet ratio ( APRI), score (NFS) prediction, also (...

BACKGROUND The area under the ROC curve (AUC) is widely used as an estimate of the diagnostic value for fibrosis markers. Whether there is variability in the AUC related to the prevalence of fibrosis stages defining advanced and nonadvanced fibrosis is unknown. The aim of this study was to assess the relationships between the AUC and the prevalence of each fibrosis stage and to elaborate simple...

The Fibrosis-4 (FIB4) index could indicate the liver fibrosis in patients with chronic hepatic diseases. It was calculated using following formula: (age × aspartate aminotransferase [U/L]) / (platelet count [103/μL] √alanine [U/L]). However, clinical impact of FIB4 acute phase heart failure (AHF) has not been sufficiently investigated.

Fibrosis is the excess deposition of extracellular matrix components which occur in multiple organs and ultimately leads to organ failure. Long noncoding RNAs (lncRNAs) are a kind of noncoding RNAs longer than approximately 200 nucleotides with no protein-encoding capacity. A growing body of evidence suggests that lncRNAs are also involved in tissues fibrosis in several organs, such as lungs fi...

The lung clearance index (LCI) measured by the multiple breath washout (MBW) test is sensitive to early disease in children with cystic fibrosis. While LCI worsens during preschool years fibrosis, there limited evidence clarify whether this continues school age years, and trajectory of progression as modifiable. A cohort (healthy fibrosis) previously studied for 12 months preschoolers were foll...

We describe an interesting case of oral sub mucous fibrosis accompanied by severe trismus in a 23 years old man. The patient had initially been diagnosed as having internal derangement of the temporomandibular joint and conservative treatment had failed to decrease the symptoms. Despite extremely limited temporomandibular joint movement, cone beam computed tomography revealed no important abnor...