We describe an innovative and tested approach combining two individually potent techniques to visualize simultaneously the functional impact of multiple projections on target populations of neurons in the brain. The rationale is simple: silence a defined set of efferent projections from one cortical region using cooling deactivation and then measure the impact of the deactivation on activities ...

Classically, the olfactory and vomeronasal pathways are thought to run in parallel non-overlapping axes in the forebrain subserving different functions. The olfactory and vomeronasal epithelia project to the main and accessory olfactory bulbs (primary projections), which in turn project to different areas of the telencephalon in a non-topographic fashion (secondary projections) and so on (terti...

Modification of spatial attention via reinforcement learning (Lee and Shomstein, 2013) requires the integration of reward, attention, and executive processes. Corticostriatal pathways are an ideal neural substrate for this integration because these projections exhibit a globally parallel (Alexander et al., 1986), but locally overlapping (Haber, 2003), topographical organization. Here we explore...

In this paper we study the impact of Minkowski metric matrix on a projection in the Minkowski Space M along with their basic algebraic and geometric properties.The relation between the m-projections and the Minkowski inverse of a matrix A in the minkowski space M is derived. In the remaining portion commutativity of Minkowski inverse in Minkowski Space M is analyzed in terms of m-projections as...

Neural circuits are organized into functional topographic maps. In order to visualize complex circuit architecture we developed an approach to reliably label the global patterning of multiple topographic projections. The cerebellum is an ideal model to study the orderly arrangement of neural circuits. For example, the compartmental organization of spinocerebellar mossy fibers has proven to be a...

The injured adult mammalian spinal cord shows little spontaneous recovery after injury. In the present study, the contribution of projections in the dorsal half of the spinal cord to functional loss after adult spinal cord injury was examined, together with the effects of transgenic cellular delivery of neurotrophin-3 (NT-3) on morphological and functional disturbances. Adult rats underwent bil...

Digital Breast Tomosynthesis (DBT) is a technology that creates three dimensional (3D) images of breast tissue. Tomosynthesis mammography detects lesions that are not detectable with other imaging systems. If image reconstruction time is in the order of seconds, we can use Tomosynthesis systems to perform Tomosynthesis-guided Interventional procedures. This research has been designed to study u...

UNLABELLED Although feedback or centrifugal projections from higher processing centers of the brain to peripheral regions have long been known to play essential functional roles, the anatomical organization of these connections remains largely unknown. Using a virus-based retrograde labeling strategy and 3D whole-brain reconstruction methods, we mapped the spatial organization of centrifugal pr...

UNLABELLED VizRank is a tool that finds interesting two-dimensional projections of class-labeled data. When applied to multi-dimensional functional genomics datasets, VizRank can systematically find relevant biological patterns. AVAILABILITY http://www.ailab.si/supp/bi-vizrank SUPPLEMENTARY INFORMATION http://www.ailab.si/supp/bi-vizrank.

The Bass (1969) model has been the standard for analyzing and predicting the market penetration of new products. Recently a new class of non-parametric techniques, known as Functional Data Analysis (FDA), has shown impressive results within the statistics community. The authors demonstrate the insights to be gained and predictive performance of Functional Data Analysis on the market penetration...