نتایج جستجو برای GABA-C receptors

تعداد نتایج: 928681  

Journal: :Current drug targets. CNS and neurological disorders 2003
Graham A R Johnston, Mary Chebib, Jane R Hanrahan, Kenneth N Mewett,

GABA(C) receptors are the least studied of the three major classes of GABA receptors. The physiological roles of GABA(C) receptors are still being unravelled and the pharmacology of these receptors is being developed. A range of agents has been described that act on GABA(C) receptors with varying degrees of specificity as agonists, partial agonists, antagonists and allosteric modulators. Pharma...

Journal: :Molecular pharmacology 2000
N Filippova, A Sedelnikova, Y Zong, H Fortinberry, D S Weiss,

Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate induced a continuous decrease in the gamma-aminobutyric acid (GABA)-activated current amplitude from recombinant GABA receptors (formed by rho1 or alphabetagamma subunits) expressed in Xenopus oocytes. This decline was due to internalization of receptors from the plasma membrane as confirmed by a decrease in surface fluores...

2002
Ian L Martin, Susan M J Dunn, Ian Martin,

Ian Martin is Professor of Pharmacology in the School of Life and Health Sciences at the University of Aston, Birmingham B4 7ET, UK. Susan Dunn is a Senior Lecturer in the Department of Pharmacology at the University of Bristol, University Walk, Bristol BS8 1TD, UK. They have common interests in GABAergic transmission in the central nervous system and their research is focused on the structure-...

Journal: :Current topics in medicinal chemistry 2002
Graham A R Johnston,

GABA(C) receptors belong to the nicotinicoid superfamily of ionotropic receptors that include nicotinic acetylcholine receptors, bicuculline-sensitive GABA(A) receptors, strychnine-sensitive glycine receptors and 5HT3 serotonin receptors. The GABA(C) receptor concept arose from medicinal chemical studies of a conformationally restricted analog of GABA. Receptors matching the predicted propertie...

Journal: :Journal of neurophysiology 2000
J L Du, X L Yang,

gamma-Aminobutyric acid (GABA) receptors on retinal bipolar cells (BCs) are highly relevant to spatial and temporal integration of visual signals in the outer and inner retina. In the present work, subcellular localization and complements of GABA(A) and GABA(C) receptors on BCs were investigated by whole cell recordings and local drug application via multi-barreled puff pipettes in the bullfrog...

Journal: :Journal of neurophysiology 1999
M Pasternack, M Boller, B Pau, M Schmidt,

We have recently found that GABA(C) receptor subunit transcripts are expressed in the superficial layers of rat superior colliculus (SC). In the present study we used immunocytochemistry to demonstrate the presence of GABA(C) receptors in rat SC at protein level. We also investigated in acute rat brain slices the effect of GABA(A) and GABA(C) receptor agonists and antagonists on stimulus-evoked...

Journal: :British journal of anaesthesia 1993
C S Goodchild,

From an historical standpoint, the development of our understanding of basic mechanisms of the actions of gamma aminobutyric acid (GABA) and benzodiazepines began on separate paths. Classical pharmacology revealed similarity between the actions of GABA and benzodiazepines in the central nervous system. Furthermore, pharmacological experiments with selective agonists and antagonists indicated th...

Journal: :Journal of neurophysiology 2005
Claudia Prada, Susan B Udin, Allan F Wiechmann, Irina V Zhdanova,

To investigate the physiological effects of melatonin receptors in the Xenopus tectum, we have used the fluorescent indicator Fluo-4 AM to monitor calcium dynamics of cells in tectal slices. Bath application of KCl elicited fluorescence increases that were reduced by melatonin. This effect was stronger at the end of the light period than at the end of the dark period. Melatonin increased gamma-...

2008
G A R Johnston, M Chebib, S P Fernandez, J R Hanrahan, T Hinton,

This article profiles ten examples of chemicals derived from herbal preparations that influence ionotropic receptors for the brain’s major inhibitory neurotransmitter g-aminobutyric acid (GABA). Many herbal medicines are used to influence brain function in order to treat anxiety, cognitive disorders, and insomnia. Such disorders are considered likely to involve GABA receptors, particularly iono...

Journal: :Journal of neurophysiology 1998
H L Gaspary, W Wang, G B Richerson,

gamma-Aminobutyric acid (GABA) transporters are electrogenic and sodium-dependent and can operate in reverse when cells are depolarized or when there is reversal of the inward sodium gradient. However, the functional relevance of this phenomenon is unclear. We have examined whether depolarization induced by a physiologically relevant increase in extracellular [K+] leads to sufficient amounts of...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید