background: mesenchymal stem cells (msc) have ability to regulate immune response via proinflamatory cytokines. in this study we aimed to investigate the effect of different mechanism for t cell activation and adjacency on immunoregulatory properties of msc. methods: bone marrow mscs were purchased and t cells were obtained from whole blood sample. t cells were activated by two different mechan...

objective(s): stem cell therapy is believed to be as a promising treatment strategy for tissue repair and regeneration. the plasticity specification of the adult stem cells, such as mscs, has enabled that these cells to be used in the treatment of a broad spectrum of diseases like liver disorders. in this study, the production of urea and albumin (alb), glycogen storage, and expression of some ...

objective(s): the main characteristic of mesenchymal stem cells (mscs) is their ability to produce other cell types. electromagnetic field (emf) stimulates differentiation of mscs into other cells. in this study, we investigated whether emf can effect on the differentiation of mscs into dopaminergic (da) neurons. materials and methods: an emf with a frequency of 50 hz and two intensities of 40 ...

objective(s) mesenchymal stem cells (mscs) are nonhematopoietic stromal cells that are capable of differentiating into and contribute to the regeneration of mesenchymal tissues. human mesenchymal stem cells (hmscs) are ideal targets in cell transplantation and tissue engineering. enhanced green fluorescent protein (egfp) has been an important reporter gene for gene therapy. the aim of this stud...

background: adipose-derived stem cells (adsc) could be an appealing alternative to bone marrow stem cells (bmsc) for engineering cell-based osteoinductive grafts. meanwhile, prior studies have demonstrated that melatonin can stimulate osteogenic differentiation. therefore, we assayed and compared the melatonin effect on osteogenic differentiation of bmsc with that of adsc. methods: mesenchymal ...

introduction: in this study, the effect of para-nonylphenol as an environmental pollutant on viability, morphology and proliferation of bone marrow mesenchymal stem cells was investigated. methods: bone marrow mesenchymal stem cells of rat were treated with the 0.5, 1, 2.5, 3.5 and 5 μm of paranonylphenol for a period of 21 days, then the viability of the cells were estimated using trypan blue ...

the identification of multipotential mesenchymal stem cells (mscs) derived from adult human tissues such as bone marrow and connective tissues has provided exciting prospects for cell-based tissue engineering and regeneration. this review article focuses on the biology of mscs, their differentiation potentials in vitro and in vivo, and their application in tissue engineering. our current unders...

conclusions based on our findings, we conclude that the separation and reproduction of adipose tissue cells is an appropriate method for purification of mscs in animal studies. regarding the histomorphometric and flow cytometry analysis results, we demonstrated the differentiation ability of mscs in normal medium and hope to employ these cells for the regeneration of damaged bone tissues in the...

human umbilical cord matrix (hucm) is considered as a promising source of mesenchymal stem cells (mscs) due to several advantages over other tissues. the potential of neural differentiation of hucm-mscs is of great interest in the context of treating neurodegenerative diseases. in recent years, considerable efforts have been made to establish in vitro conditions for improving the differentiatio...

objective:more similarity to in vivo medium may help to increase the proliferation and differentiation of cells at in vitro condition. the present study has investigated the effect of a dynamic mediumand nano hydroxyapatite (nha) presence on proliferation and differentiation of mesenchymal stem cells (mscs) to bone cells using electrospun polycaprolactone (pcl) scaffolds. methods: we prepared p...