This paper describes the program execution framework being developed by the Grid Application Development Software (GrADS) Project. The goal of this framework is to provide good resource allocation for Grid applications and to support adaptive reallocation if performance degrades because of changes in the availability of Grid resources. At the heart of this strategy is the notion of a configurab...

Grid computing platforms require to handle dynamic behaviour of computing resources within complex parallel applications. We introduce a formalization of adaptive behaviour that separates the abstract model of the application from the implementation design. We exemplify the abstract adaptation schema on two applications, and we show how two quite different approaches to adaptivity, the ASSIST e...

Sarcoidosis is a systemic disease characterized by noncaseating granulomatous inflammation with tremendous clinical heterogeneity and uncertain pathobiology and lacking in clinically useful biomarkers. The Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study is an observational cohort study designed to explore the role of the lung microbiome and genome in these two d...

Finding your passion is key to success, Brian Kobilka, MD, said in a speech June 15 at the School of Medicine commencement. In his usual self-deprecating manner, the Stanford scientist, who was awarded the Nobel Prize in chemistry last year, minimized his credentials and credited support from others for much of his success. “I believe my career to date is an example of how a relatively average ...

Survey cards were distributed to the leukemic patients in the departments of internal medicine and pediatrics of hospitals in Japan from 1961 to 1965, with requests for the name, sex, type and date of onset of disease, and type and frequency of prior medical irradiation. Of 1,197 available cards collected, 49 or 4.09 per cent had a history of fluoroscopic examination and 19 or 1.59 per cent had...

Many graduates exit TAFE or University studies with a casual or volunteer position and a promising future. However, many more have no idea how to get that elusive dream job or to further the position they already have. As a new graduate of the TAFE Diploma of Library and Information Services, I have been a volunteer, a casual employee at four jobs (at the same time), and now aim to become an ac...

Advances in networking technologies will soon make it possible to use the global information infrastructure in a qualitatively different way—as a computational as well as an information resource. As described in the recent book “The Grid: Blueprint for a New Computing Infrastructure,” this “Grid” will connect the nation’s computers, databases, instruments, and people in a seamless web of comput...