conclusions due to the significant reduction in the mean inactivation dose of colon cancer cells in the presence of gold nanoparticles, it seems that gnps are suitable options to achieve a new approach in order to improve radiotherapy efficiency without increasing the prescribed radiation dose. results cell survival in the presence of gnps was more than 90% and the maximum uptake of gnps was ob...

Background and objectives: Natural products are one of the major sources for investigations of novel medicines. Zataria multiflora Boiss (ZM) has shown pharmacological activities especially in gastrointestinal tract; however, there are limited studies about its cytotoxicity effects. In this study, the effect of Zataria multiflora was examined on two colon canc...

Objective(s): The purpose of this study was to investigate cytotoxicity and membrane toxicity effects induced by Mesobuthus eupeus venom (MEV) on the HT-29 cell line. Materials and Methods: To determine the in vitro cytotoxicity via MTT assays, HT-29 (as cancer cell line) and Hek-293T (as normal cell) were treated through different conce...

apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. caspases, a family of cysteine-dependent aspartate-directed proteases, play a critical role in the initiation and execution of apoptosis. in this study, cytotoxicity and apoptogenic effect of 2-phenyl 4-carboxamide derivatives were evaluated in sknmc (huma...

Background and Objective: Mesenchymal stem cells (MSCs) promote metastasis in colorectal cancer; however, the mechanism underlying this process is not fully understood. Epithelial to mesenchymal transition (EMT) is a key step in tumor acquisition of metastatic phenotype. We aimed to investigate the effect of MSCs on the expression of EMT markers, as well as cancer stem cell markers in HT-29 col...

Mesenchymal Stem Cells Trigger Epithelial to Transition in the HT-29 Colorectal Cancer Cell Line

objective: lactobacilli are a group of probiotics with beneficial effects on prevention of cancer. however, there is scant data in relation with the impacts of probiotics in late-stage cancer progration, especially metastasis. the present original work was aimed to evaluate the anti-metastatic and anti-proliferative activity of lactobacillus rhamnosus supernatant (lrs) and lactobacillus crispat...