Background and Purpose: Hepatitis B is a major health problem around the globe the prevalence of which varies depending on the region and study. In this study, we aimed to determine the epidemiology and prevalence rates of hepatitis B in Fasa, Iran. Methods: This descriptive, cross-sectional study was performed using medical records of all the hepatitis B patients referring to Fasa Health Cent...

Background & Aims: Hepatitis B virus is one of the causes of acute and chronic hepatitis. Due to multiple hospitalization and blood transfusion, thalassaemic patients are at higher risk of this infection. Duration of the immunity after vaccination in this high-risk group and the need for booster vaccination is uncertain. The aim of this study was to find antibody titration and immunity to Hepat...

HBs vaccines were prepared by three different methods: 1) Heat inactivation (Krugman, et.al 1971)2) Ammonium sulphate precipitation followed by column chromatography (Sephadex G-200) 3) PEG-6000 (polyethylene glycol) precipitation followed by column chromatography using Sephadex G-200. Their efficacy was studied in guinea pigs, and the results compared with commercial Japanese vaccine (Gr...

Hepatitis B virus (HBV) is an etiological agent of hepatitis B infection. Hepatitis B is a life-threatening disease that affects the liver. The clinical outcomes of the disease are varied from asymptomatic disease to serious complication such as cirrhosis and hepatocellular carcinoma (HCC). Despite availability of the vaccine and appropriate treatment, hepatitis B infection still remains a majo...

background and objective: presence of hepatitis b core antibody (anti-hbc) in the absence of hepatitis b surface antigen (hbsag) and hepatitis b surface antibody (anti-hbs) is defined, as isolated anti-hbc. little is known about the clinical significance of the isolated anti-hbc in hepatitis b virus (hbv) infections. the aim of this study was to assess the significance of anti-hbc as the only m...

objective (s):the aim of this study was to determine the correlation between vaccine therapy and appearance of mutations in hepatitis b surface antigen (hbsag)-positive chronic hepatitis b virus (hbv) patients. materials and methods: 16 patients received the hbv vaccine and another 16 individuals from the control group did not. the surface gene was amplified and directly sequenced from samples ...

conclusions we introduced an anti-hbsp antibodies elisa, designed for locally circulating hbv strains. correlation observed of anti-hbsp with liver fibrosis staging regardless of viral replication and liver inflammation suggests anti-hbsp antibodies as possible indicator for hbv-associated liver fibrosis. results seven out of eighty (9%) chb patients were positive for anti-hbsp antibodies. mean...