نتایج جستجو برای Hippocampal slices

تعداد نتایج: 42892  

2011
Gaston Calfa, John J. Hablitz,

1 FROM Mecp2 MUTANT MICE REVEALED BY VOLTAGE2 SENSITIVE DYE IMAGING 3 4 Gaston Calfa, John J. Hablitz and Lucas Pozzo-Miller 5 6 Department of Neurobiology, Civitan International Research Center, 7 The University of Alabama at Birmingham, Birmingham, AL 35294, USA. 8 9 10 56 pages with 8 Figures, and 3 Supplemental Figures 11 12 Running title: Hippocampal hyperexcitability in Mecp2 mutant mice ...

Journal: :Journal of neurophysiology 2003
Don Kubota, Laura Lee Colgin, Malcolm Casale, Fernando A Brucher, Gary Lynch,

Sharp waves (SPWs) are thought to play a major role in intrinsic hippocampal operations during states in which subcortical and cortical inputs to hippocampus are reduced. This study describes evidence that such activity occurs spontaneously in appropriately prepared rat hippocampal slices. Irregular waves, with an average frequency of approximately 4 Hz, were recorded from field CA3 in slices p...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1983
G Barrionuevo, T H Brown,

Interactions between two excitatory monosynaptic inputs to hippocampal neurons of the CA1 region were examined in the in vitro slice. By adjusting the strengths of the electrical stimuli delivered to the two input pathways, one was made to generate a weak and the other a strong synaptic response. Simultaneous tetanic stimulation of both input pathways resulted in a subsequent long-term enhanced...

2011
Filip de Vin, Joris H. De Maeyer, Romain A. Lefebvre,

5-HT4 receptor (5-HT4R) activation induces pro-cognitive effects. This might be related to stimulation of hippocampal acetylcholine (ACh) release, which has been shown for 5-HT4R agonists in in vivo models. We investigated the influence of the 5-HT4R agonists prucalopride and BIMU-8 on ACh release in rat hippocampal brain slices. In contrast to the report by Siniscalchi et al. [1], no facilitat...

Journal: :Cryobiology 2006
Yuri Pichugin, Gregory M Fahy, Robert Morin,

Although much interest has attended the cryopreservation of immature neurons for subsequent therapeutic intracerebral transplantation, there are no reports on the cryopreservation of organized adult cerebral tissue slices of potential interest for pharmaceutical drug development. We report here the first experiments on cryopreservation of mature rat transverse hippocampal slices. Freezing at 1....

Journal: :Acta neurobiologiae experimentalis 1979
V G Skrebitsky, V S Vorobyev,

Long-lasting potentiation in the hippocampal pathways is used at present as a model for long-term plasticity in the nervous system. In this study post-tetanic potentiation was investigated in the dentate gyrus-area CA3 pathway by extra- and intracellular recordings from transverse slices of the mouse hippocampus. Tetanization of the dentate gyrus led to a reduction in the latency of action pote...

2010
Morad Zahid, Mateo Vélez-Fort, Eirini Papagiakoumou, Cathie Ventalon, María Cecilia Angulo, Valentina Emiliani,

BACKGROUND Advanced light microscopy offers sensitive and non-invasive means to image neural activity and to control signaling with photolysable molecules and, recently, light-gated channels. These approaches require precise and yet flexible light excitation patterns. For synchronous stimulation of subsets of cells, they also require large excitation areas with millisecond and micrometric resol...

2013
Maura M. Zylla, Xiaomin Zhang, Susanne Reichinnek, Andreas Draguhn, Martin Both,

The mammalian hippocampus expresses several types of network oscillations which entrain neurons into transiently stable assemblies. These groups of co-active neurons are believed to support the formation, consolidation and recall of context-dependent memories. Formation of new assemblies occurs during theta- and gamma-oscillations under conditions of high cholinergic activity. Memory consolidat...

2002
Ken Shimono, Michel Baudry, Lam Ho, Makoto Taketani, Gary Lynch,

Long-term potentiation (LTP) was elicited by high frequency stimulation in hippocampal slices cultured on multi-electrode arrays. LTP lasting more than 1 h was recorded in 75% of slices, and a significant number of slices exhibited a non-decaying LTP that lasted more than 48 h. LTP induction was completely and reversibly blocked by an antagonist of the NMDA receptor, APV. Our results suggest th...

Journal: :The Journal of physiology 2014
Takuya Sasaki, Tomoe Ishikawa, Reimi Abe, Ryota Nakayama, Akiko Asada, Norio Matsuki, Yuji Ikegaya,

Astrocytes are thought to detect neuronal activity in the form of intracellular calcium elevations; thereby, astrocytes can regulate neuronal excitability and synaptic transmission. Little is known, however, about how the astrocyte calcium signal regulates the activity of neuronal populations. In this study, we addressed this issue using functional multineuron calcium imaging in hippocampal sli...

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