Abstract Reactive oxygen species (ROS) are not only toxic agents but also potent signaling molecules. NADPH oxidases the sole enzymes to generate ROS playing an important role in redox signaling. They closely interact several ways with hypoxia-inducible transcription factors of HIF family. This network is active under normoxic and hypoxic conditions as regulator homeostasis. Members oxidases-HI...

The optimization of conditions to promote the stemness pluripotent cells in vitro is instrumental for their use advanced therapies. We show here that exposure human iPSCs and ESCs low concentrations chemical NO donor DETA/NO leads stabilization hypoxia-inducible factors (HIF-1α HIF-2α) under normoxia, with this effect being dependent on diminished Pro 402 hydroxylation decreased degradation by ...

This study analyzed the time dependence decay of the mRNA of selected genes important for the hypoxia response. The genes chosen were the two isoforms of hypoxia-inducible factors, the three isoforms of the prolyl hydroxylase domain protein, the vascular endothelial growth factor and endothelial nitric oxide synthase. mRNA and proteins were extracted from lungs obtained from control, hypoxic an...

Hepcidin inhibits iron uptake from the gut and release of iron from macrophages in the reticuloendothelial system. Suppression of plasma hepcidin occurs in lowlanders after ascent to high altitude, reflecting the increased iron demand for erythropoiesis, but the mechanism and primary stimulus for hepcidin suppression in this setting remains unclear. It has been suggested that hypoxia per se, po...