Hypoxia-inducible factor (HIF-1) regulates the expression of genes that facilitate tumor cell survival by making them more resistant to therapeutic intervention. Recent evidence suggests that the activation of other transcription factors, in cooperation with HIF-1 or acting alone, is involved in the upregulation of hypoxia-inducible genes. Here we report that high cell density, a condition that...

Ischemic heart disease, resulting from ischemic and anoxic cardiomyocytes, can lead to the abnormal metabolic activity which is able result in some serious diseases including cardiac failure, thrombus other deadly disease it also bad factor health of human. Besides, oxidative stress one most factors this destroy healthy tissue, protein so on. Hypoxia, as a signal, launch hypoxia-inducible 1-alp...

Hypoxia plays a critical role in coordinating cell survival, differentiation and death in normal embryogenesis; during limb pattern formation, hypoxia affects two key processes, chondrogenesis and cell death. Hypoxia promotes chondrocyte differentiation and cartilage matrix synthesis and suppresses terminal differentiation. Depending on the context, hypoxia may induce cell cycle arrest, pro- or...