نتایج جستجو برای IBD

تعداد نتایج: 5482  

2017
Nuggehally R Srinivas,

While new options of treatment and management of inflammatory bowel disease (IBD) are being continuously explored [1-3], the introductions of biological products such as infliximab and adalimumab, both of which are tumour necrosis factor (TNF)alpha inhibitors, have indeed provided therapeutic options for many IBD patients.4 The likely introductions of other biosimilar versions of both inflixima...

Journal: :Inflammatory bowel diseases 2017
Stephan R Vavricka, Martin Gubler, Claudine Gantenbein, Muriel Spoerri, Florian Froehlich, Frank Seibold, Marijana Protic, Pierre Michetti, Alex Straumann, Nicolas Fournier, Pascal Juillerat, Luc Biedermann, Jonas Zeitz, Benjamin Misselwitz, Michael Scharl, Henriette Heinrich, Christine N Manser, Ekaterina Safroneeva, Raja Affendi Raja Ali, Gerhard Rogler, Alain M Schoepfer, Thomas Greuter,

BACKGROUND Extraintestinal manifestations (EIMs) in patients with inflammatory bowel disease (IBD) are frequently observed. Little is known about the efficacy of anti-tumor necrosis factor (TNF) in EIM management. We assessed the effect of 3 anti-TNF agents (infliximab, adalimumab, and certolizumab pegol) on EIM evolution. METHODS Data on 1249 patients from the Swiss IBD Cohort Study (SIBDCS)...

2017
John D Delaney, John T Holbrook, Robert K Dewar, Patrick J Laws, Alexander F Engel,

OBJECTIVE To assess the level of equivocation among level 1 evidence in ulcerative colitis and Crohn's disease and determine whether any predisposing factors are present. METHOD MEDLINE, Embase, CINHAL and Cochrane were searched from 2006 to 2017. Papers were scored using AMSTAR and categorised into surgical (S), medical (M) or medical and surgical (MS) groups. The ability of each paper to ma...

2017
Xiang Peng, Min Zhi, Ming Wei, Ting-Ting Li, Min Zhang, Yuan-Qi Zhang, Huan He, Mingli Su, Wei Wang, Jun-rong Chen, Jian Tang, Xiang Gao, Pin-Jin Hu, Xiao-Yan Liang,

The effectiveness of thalidomide in treating inflammatory bowel disease (IBD) has been widely recognized. Meanwhile, many serious adverse drug reactions have been observed, but no know reports on ovarian reserve function.Female patients, ranging in age between 18 and 40, were referred to our institution to undergo sex hormone detection and ultrasonic scanning for ovarian function assessment, be...

Journal: :Histology and histopathology 2011
Helmut Neumann, Michael Vieth, Raja Atreya, Markus F Neurath, Jonas Mudter,

BACKGROUND AND AIMS Confocal laser endomicroscopy (CLE) represents a novel endoscopic imaging technique which enables the in vivo microscopic imaging within the mucosal layer of the gut at subcellular resolution. Currently, there are no data available on the learning curve of CLE, which was therefore the aim of our study. METHODS Twenty-six consecutive patients with inflammatory bowel disease...

2017
Varun Chandrashekaran, Ratanesh K. Seth, Diptadip Dattaroy, Firas Alhasson, Jacek Ziolenka, James Carson, Franklin G. Berger, Balaraman Kalyanaraman, Anna Mae Diehl, Saurabh Chatterjee,

Recent clinical studies found a strong association of colonic inflammation and Inflammatory bowel disease (IBD)-like phenotype with NonAlcoholic Fatty liver Disease (NAFLD) yet the mechanisms remain unknown. The present study identifies high mobility group box 1 (HMGB1) as a key mediator of intestinal inflammation in NAFLD and outlines a detailed redox signaling mechanism for such a pathway. NA...

2017
Reza Karbalaei, Mehran Piran, Mostafa Rezaei-Tavirani, Hamid Asadzadeh-Aghdaei, Mohammad Hossein Heidari,

Aim Analysis reconstruction networks from two diseases, IBD and NASH and their relationship, based on systems biology methods. Background IBD and NASH are two complex diseases, with progressive prevalence and high cost for countries. There are some reports on co-existence of these two diseases. In addition, they have some similar risk factors such as age, obesity, and insulin resistance. Ther...

Journal: :Gut 2005
I D R Arnott, G-T Ho, E R Nimmo, J Satsangi,

There is now strong evidence implicating the enteric flora in the aetiopathogenesis of inflammatory bowel disease (IBD), and identification of CARD15 (NOD2) as a pattern recognition receptor (PRR) has given novel insights into host-bacteria interactions. CARD15 is implicated as the intracellular sensor of muramyl dipeptide, a highly conserved bacterial peptidoglycan motif, and raises the questi...

2015
David J. Cutler, Michael E. Zwick, David T. Okou, Sampath Prahalad, Thomas Walters, Stephen L. Guthery, Marla Dubinsky, Robert Baldassano, Wallace V. Crandall, Joel Rosh, James Markowitz, Michael Stephens, Richard Kellermayer, Marian Pfefferkorn, Melvin B. Heyman, Neal LeLeiko, David Mack, Dedrick Moulton, Michael D. Kappelman, Archana Kumar, Jarod Prince, Promita Bose, Kajari Mondal, Dhanya Ramachandran, John F. Bohnsack, Anne M. Griffiths, Yael Haberman, Jonah Essers, Susan D. Thompson, Bruce Aronow, David J. Keljo, Jeffrey S. Hyams, Lee A. Denson, Subra Kugathasan, Fabio Cominelli,

BACKGROUND The inflammatory bowel diseases (IBD) are common, complex disorders in which genetic and environmental factors are believed to interact leading to chronic inflammatory responses against the gut microbiota. Earlier genetic studies performed in mostly adult population of European descent identified 163 loci affecting IBD risk, but most have relatively modest effect sizes, and altogethe...

2014
Aashiq H. Mirza, Simranjeet Kaur, Caroline A. Brorsson, Flemming Pociot,

Long non-coding RNAs are a new class of non-coding RNAs that are at the crosshairs in many human diseases such as cancers, cardiovascular disorders, inflammatory and autoimmune disease like Inflammatory Bowel Disease (IBD) and Type 1 Diabetes (T1D). Nearly 90% of the phenotype-associated single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies (GWAS) lie outside of t...

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