tetracyclines are broad spectrum antibiotics which are inexpensive and widely available and have an appropriate safety profile. in addition to antibiotical effects, tetracyclines can inhibit matrix metaloproteinase and collagenase, and subsequently reduce inflammation, angiogenesis, and neovascularization. they have partial neuro-protective, anti-apoptotic and antioxidant properties. given thes...

objective(s):resveratrol (res) is a polyphenol compound that has been shown a promising cardioprotective effect. however, some reports have yielded conflicting findings. herein, we investigated the anti-atherosclerotic effects of res in apolipoprotein e (apo e)-deficient mice on a high cholesterol diet. materials and methods: firstly, atherosclerosis was induced by feeding a high cholesterol di...

objective(s): fluvoxamine is a well-known selective serotonin reuptake inhibitor (ssri); despite its anti-inflammatory effect, little is known about the precise mechanisms involved. in our previous work, we found that ip administration of fluvoxamine produced a noticeable anti-inflammatory effect in carrageenan-induced paw edema in rats. in this study, we aimed to evaluate the effect of fluvoxa...

objective(s): the effect of the extract of crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined.   materials and methods: ovalbumin (oa) sensitized guinea pigs were given drinking water alone (group s), or drinking water containing three concentrations of safranal, three concentrations of extract and one concentration of dexamethasone, (n=6...

most common hypotheses of seizure initiation are increased neural excitation, decreased inhibition or both. but, the conditions that lead to these activation states not to be clear yet. recent studies challenge traditional concepts and indicate new evidence that a key epileptogenic process may actually begin in the blood vessel. seizures could be initiate by a variety of insults to the brain, s...

background: asthma is a chronic inflammatory disease with multifactorial and complicated mechanisms. elevated level of exhaled nitric oxide (no) in asthma and other inflammatory lung diseases has led to many studies examining no as a potential marker of airway inflammation. objective: this study was designed to determine the level of no in bronchoalveolar lavage (bal) fluid during early and lat...

abstract objective: obesity is related to anemia which is explained its mechanism as disorder in iron absorption but the more rational reason is anemia of inflammation or anemia of chronic disease. the aim of this study was to define the prevalence of obesity in patients with normochromic normocytic anemia. materials and methods: we screened 406 patients who were referred to endocrine clinic. t...

conclusions maximal and supra-maximal races induce a significant increase in lipid peroxidation and cause non-negligible inflammation and muscle damage. these effects were relatively related to the physical exercise type and the sportive specialty. results a significant increase in malondialdehyde (mda) concentrations was observed in ss and mdr after the vameval test and in ldr after the limite...

quercetin is a dietary flavonoid which has anti-inflammatory effects. this study aimed to evaluate the influence of quercetin on histopathological aspects and airway epithelium in  allergic airway  inflammation mice model. twenty-eight balb/c mice were randomly divided into four groups: group i (control), group ii (untreated mice with allergic airway inflammation), group iii (allergic airway in...

the drug pump protein mrp2 is a membrane drug efflux transporter widely distributed in normal and tumor tissues. its role is thought to be crucial for the disposition of many drugs and their substrates in different tissues. in this study, we aimed to examine the effects of systematic inflammation induced by lipopolysaccharide (lps) on the expression and function of this transporter in rats. jug...