it has been suggested that prf might possibly have an effect on the immune cells. we considered using the intravenous route to apply prf in conditions that are caused by an unresolved immune action or connected to allostatic load, implicating an abnormally reacting immune system to obtain a systemic effect that could possibly be an additional tool in treating some of these conditions. these man...

background and aims. the aim of present study was to investigate pulp-dentin complex reactions following direct pulp capping (dpc) with calcium hydroxide [ca(oh)2] and simvastatin as pulp-capping materials in the primary human molars. materials and methods. 120 primary molar teeth which had to be extracted for orthodontic reasons were randomly allocated into four groups. group ι as a control, u...

introduction: gutta-percha (gp), is a neutral and non-toxic material. the aim of this animal study was to compare the biocompatibility of nanosilver coated gp (ns-gp) with conventional gp in subcutaneous tissues in a rat model. methods and materials: conventional gp and ns-gp were subcutaneously implanted in the backs of 20 male wistar rats ( n =10). a control animal was assigned for each trial...

the empiric antibiotic therapy can result in antibiotic overuse, development of bacterial resistance and increasing costs in critically ill patients. the aim of the present study was to evaluate the effect of procalcitonin (pct) guide treatment on antibiotic use and clinical outcomes of patients admitted to intensive care unit (icu) with systemic inflammatory response syndrome (sirs).  a total ...

b a ckground: the objective was to investigate the relationship between serum interleukin-18 (il-18), pentraxin 3 (ptx3), and high-sensitivity c-reactive protein (hs-crp) levels with body mass index (bmi) and abdominal obesity and also the interaction between genetic variants of apolipoprotein a-ii (apo a-ii) and obesity on the levels of these factors in type 2 diabetes patients (t2d). m ethods...

auto-inflammatory syndromes are a new group of distinct hereditable disorders characterized by episodes of seemingly unprovoked inflammation (most commonly in skin, joints, gut, and eye), the absence of a high titer of auto-antibodies or auto-reactive t cells, and an inborn error of innate immunity. a narrative literature review was carried out of studies related to auto-inflammatory syndromes ...

asthma is a chronic inflammatory disease of the airway with extensive airway remodeling. the ethical issues associated with the studies in asthmatic patients, required development of animal model of asthma. animal models of asthma can provide valuable information on several features of asthma pathogenesis and treatment. although these models cannot carry out all clinical features, they are valu...

the effect of chronic inflammation induced by complete freund's adjuvant (cfa) on anterior blood vessels of knee joint and its diameter was studied. blood flow changes in response to phenylephrine (αl-adrenoceptor agonist) in cfa-treated and contralateral knee joints were observed over a 40-day period, using laser doppler flowmetery (ldf) technique. unilateral injection of cfa (0.2 ml) inc...

background: exercise can change the release of numerous cytokines and modulate their receptor systems. dietary ω-3 lipids may decrease the levels of inflammatory cytokines and prostaglandins (pgs). therefore, in this study, we investigated the effects of exercise and eicosapentaenoic acid (epa) supplementation, with or without vitamin e, on the blood levels of il-2, tnf-α, catalase, glutathione...

objective: non-specific cervicitis or inflammatory changes in a smear report are common which are usually unclear for clinical approaches. to investigate the frequency of inflammation and pathogenic vaginal microorganisms in cervical smears among an iranian population sample. materials and methods: this cross-sectional study was carried out on pap smear samples of women referred to gynecologica...