BACKGROUND The role and relationship between pro- and anti-inflammatory cytokines represents one of the least studied aspects of the pathogenesis of community-acquired pneumonia (CAP). The aim of the present study was to evaluate pro- and anti-inflammatory cytokines at both local (lung) and systemic (blood) levels and their relationship with the severity of the disease on admission and time for...

background: endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood, with an altered immunity as a possible key factor. the present study aimed to investigate the serum anti-inflammatory cytokine profile in the patients with endometriosis compared with the healthy controls. materials and me...

BACKGROUND Severe pathogenic infection triggers excessive release of cytokines as part of the massive inflammatory response associated with septic shock. OBJECTIVES To investigate the protective effect of caffeic acid phenethyl ester (CAPE) against lipopolysaccharide (LPS) induced endotoxemia, hepatic and neuronal damage and the associated systemic inflammatory response (SIR). METHODS Fifty...

fertility in the male is dependent on the proper production of sperm cells. this process, called spermatogenesis is very complex and involves the synchronization of numerous factors. the presence of pro–inflammatory cytokines, tumor necrosis factor-alpha (tnf–α), interleukin–1 alpha (il–1 α) and interleukin 1 beta (il–1 β) cytokines in the male reproductive tract (testis, epididymis and sperm) ...

Neuro-inflammation is a reaction to brain injury involving the activation of glial cells and release of inflammatory mediators, such as cytokines and chemokines which has a key role in neuro-degenerative diseases. Periodontitis is a microbiome-related dental inflammation caused by gram- negative bacteria that leads to connective tissue destruction and loss of teeth. Previous studies demonstrated...

The viruses that most commonly affect human respiratory tract include rhinoviruses, syncytial (RSVs), influenza, and coronaviruses (CoVs). virus infection of the epithelial cells triggers an inflammation accompanied by release pro-inflammatory cytokines/chemokines including IL6, IL8 (CXCL8), IL1?, tumor necrosis factor ? (TNF?). transition to acute inflammatory phase in lungs is increase produc...

Substance use/abuse is one of the main causes depressive symptoms. Cannabis and synthetic cannabinoids in particular gained significant popularity past years. There an increasing amount clinical data associating such compounds with inflammatory component depression, indicated by up-regulation pro-inflammatory cytokines. Pro-inflammatory cytokines are also well-known to regulate enzymes kynureni...

Human macrophages are reprogrammed by graphdiyne oxide from M2 to M1 macrophages, leading degradation of GDYO through a peroxynitrite-driven pathway with subsequent modulation pro-inflammatory cytokines including IL-1?.

Obesity is strongly associated with the degree of inflammation characterised by proinflammatory cytokines, such as tumour necrosis factor-? (TNF-?). Lifestyle modification exercise right strategy because it can stimulate interleukin 6 (IL-6) secretion which acts an anti-inflammatory. This study aimed to analyse response interval and continuous inflammatory markers in obese women. Twenty-four wo...