Abstract Background Rapid infliximab (IFX) infusions have shown to be safe in adults with inflammatory bowel disease (IBD), but data on its safety paediatric IBD is limited. This study aimed assess the frequency and timing of infusion reactions (IR) children who received rapid (1-h) vs. standard (2-h) IFX infusions. Methods retrospective cohort included patients 4-18 years old, treated between ...

The pharmacokinetics of continuous subcutaneous cytosine arabinoside (ara-C) infusions were compared with continuous intravenous infusions. Steady-state serum ara-C levels and myelosuppression were similar with both routes of administration. CSF/serum ara-C ratios ranged from 0.14 to 0.91 (mean, 0.58). Continuous subcutaneous ara-C infusions were a convenient and reliable alternative to intrave...

The anti-peroxyl radical quality of two aqueous rooibos infusions and solutions of their most abundant glycosylated polyphenols was evaluated using pyrogallol red and fluorescein-based oxygen radical absorbance ratios. It was observed that the artificial infusions, prepared using only the most abundant polyphenols present in rooibos and at concentrations similar to those found in the natural in...

A high saturated fat and fructose diet leads to metabolic disorders through dysregulation of genes involved in lipid metabolism. Consumption of plant infusions reduces these obesity alterations, but the precise mechanism remains unclear. In this study, we investigated the effect and the possible mechanism of Ocimum sanctum L. (OS) and Citrus paradisi (CP) infusions in diet-induced obese rats. C...

BACKGROUND Standard Infliximab infusion consists of a 2-hour intravenous administration. Recently, Infliximab shortened infusion has been included in the Infliximab label as possible maintenance regimen for patients tolerating Infliximab induction therapy. AIM To verify if accelerated 1-hour Infliximab infusions are as safe as standard administrations, in patients with Inflammatory Bowel Dise...

The utilization of food industrial by-products, especially pomace after juice processing, could be a big challenge. Chokeberry is valuable source phenolic compounds, including procyanidins and anthocyanins. These compounds have, e.g., antioxidant, anticancer, hypoglycemic, hypotensive, hepatoprotective cardioprotective effects. In this work, dried chokeberry (2.0 g, 2.5 g 3.0 g) was added to gr...

it has been well established that the secretions of thyroid hormones and growth hormone (gh) isunder the regulation of different neurotransmitters. the goal of this study was to determine whethersubstance-p, as a neurotransmitter, regulates the mean plasma concentrations of thyroxin (t4),triiodothyronine (t3), gh, milk amount and constituents in sanan goats. nine sanan goats were randomlydivide...