PAGE INTRODUCTION. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 Nomenclature and descriptions.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Material. ....................................................................... Methods. .........................

The building block hypothesis implies that the epistatic property of a given problem must be connected well to the linkage property of the employed representation and crossover operator in the design of genetic algorithms. A good handling of building blocks has much to do with topological linkages of genes in the chromosome. In this paper, we provide a taxonomy of the approaches that exploit to...

Rheumatoid arthritis is a complex disease in which environmental factors interact with genetic factors that influence susceptibility. Incorporating information about related quantitative traits or environmental factors into linkage mapping could therefore greatly improve the efficiency and precision of identifying the disease locus. Using a multipoint linkage approach that allows the incorporat...

Based on longitudinal twin data in women, we have previously demonstrated a genetic influence on changes in lipoprotein risk factors, blood pressure measurements, and body mass index over a decade. The present study examined the linkage between changes in lipoprotein variables and candidate genes encoding the hormone-sensitive lipase (HSL), hepatic lipase (HL), and lipoprotein lipase (LPL). The...

This paper describes fundamental principles for two dimensional pattern design of folded robots, specifically mobile robots consisting of closed-loop kinematic linkage mechanisms. Three fundamental methods for designing closed-chain folded four-bar linkages – the basic building block of these devices – are introduced. Modular connection strategies are also introduced as a method to overcome the...

This paper describes a Java-based architecture for a computer-aided-design system for spatial linkages. These linkages are formed by a workpiece supported by one or more serial chains. The task of the linkage is defined by specifying rigid positions for the workpiece that approximate a desired workspace. Because there are many serial chains available for this design process, the architecture is...