The power of linkage analysis of a quantitative disease endophenotype was compared for the following family selection designs: 1) Random samples: randomly chosen nuclear families, 2) "coronary artery calcification (CAC)" samples: selection of each nuclear family through a proband with abnormally high levels of the simulated quantitative endophenotype, CAC, and (3) "MI" samples: selection of eac...

Bipolar disorder is a common, heritable mental illness characterized by recurrent episodes of mania and depression. Despite considerable effort to elucidate the genetic underpinnings of bipolar disorder, causative genetic risk factors remain elusive. We conducted a comprehensive genomic analysis of bipolar disorder in a large Old Order Amish pedigree. Microsatellite genotypes and high-density S...

Emissions trading schemes have emerged as stable components in a fragmented climate governance landscape, yet the proliferation of such raises critical questions concerning their design, development conflicting norms, and how might link. This opinion recognizes contribution linkage between emissions identifies fostering complementarity pre-emptive prevention emergence conflictive scheme design ...

The domesticated silkworm, Bombyx mori, is of high commercial importance as a silk producer and is also widely used for implementation of basic and applied research. It is important to understand its genome organization using molecular markers for genetic studies and for breeding purposes. In this study, a genetic linkage map using 204 amplified fragment length polymorphism (AFLP) markers was d...

Abstract Implementation of biomimetics in practical innovation strategies still faces various impediments. Multidisciplinary communication is one the most recognized one. Enabling teammates having cognitive and conceptual frameworks to properly exchange information a key lever for optimization. In previous study, we performed comparative analysis biologists’ engineers’ order support establishme...

BACKGROUND AND AIMS Inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn's disease, both of which are multifactorial diseases involving the interaction of genetic and environmental factors. A region on chromosome 12 centred around the marker locus D12S83 has previously been associated with IBD predisposition. The aim of the study was to investigate this genetic region in an in...