OBJECTIVE Despite its large clinical impact, the underlying mechanisms for vein graft failure remain obscure and no effective therapeutic solutions are available. We tested the hypothesis that Notch signaling promotes vein graft disease. APPROACH AND RESULTS We used 2 biotherapeutics for Delta-like ligand 4 (Dll4), a Notch ligand: (1) blocking antibody and (2) macrophage- or endothelial cell ...

Human monocyte-derived macrophages secrete lipoprotein lipase (LPL) in culture. The regulation of human macrophage LPL production is poorly understood. Since bacterial lipopolysaccharide (LPS) alters production of several macrophage secretory products, its effect on human monocyte-derived macrophage LPL was tested. LPS treatment produced a dramatic dose-dependent decrease in LPL activity in mac...

M2 tumor-associated macrophage has been found to play a supportive role in the progression of glioma. The underlying mechanism, nevertheless, has been largely unknown. In our study, to investigate how M2 macrophage played role in glioma, firstly we've analyzed the clinicopathological significance of M2 macrophage existence on clinical tissues of glioma using detection of CD163 expression with i...

BACKGROUND Advanced glycation end products (AGEs), inflammatory-associated macrophage migration and accumulation are crucial for initiation and progression of diabetic vascular complication. Enzymatic activity of heparanase (HPA) is implicated strongly in dissemination of metastatic tumor cells and cells of the immune system. In addition, HPA enhances the phosphorylation of selected signaling m...

Macrophage Fcgamma receptors (FcgammaRs) play an important role in the host defense against infection and in the pathophysiology of immune cytopenias. Modulation of macrophage FcgammaR expression is a potential therapeutic approach to immune disorders. Glucocorticoids and progesterones decrease macrophage FcgammaR expression. We assessed the effect of treatment with androgens and antiandrogens ...

Infectious diseases occur when a pathogen overwhelms a host`s immune response, establishes a local niche, replicates and spreads over the whole body. Immunocompromised people are especially in danger to develop severe pathologies. An important factor influencing the immune defence is the diet. In particular polyunsaturated fatty acids (PUFA) are believed to play a key role in modulating immune ...

OBJECTIVES/HYPOTHESIS Granulocyte/macrophage colony-stimulating factor is important in the pathogenesis of acute and chronic inflammatory disease. We hypothesized that granulocyte/macrophage colony-stimulating factor plays a pivotal role in middle ear inflammation and that neutralization of granulocyte/macrophage colony-stimulating factor would inhibit neutrophil migration into the middle ear a...

BACKGROUND/AIM Macrophages are important components of human defense systems and consequently key to antitumor immunity. Human-serum macrophage activation factor (serum MAF) can activate macrophages, making it a promising reagent for anticancer therapy. MATERIALS AND METHODS We established four different macrophage subtypes through introduction of different culture conditions to THP-1- and U9...

Abstract Backgrounds The present study explored the viability of bovine milk macrophages, their intracellular production reactive oxygen and nitrogen species (RONS), phagocytosis Staphylococcus aureus , as well profile lymphocytes, from healthy udder quarters infected by Corynebacterium bovis . included 28 12 dairy cows 20 C. 10 cows. percentages macrophages lymphocytes were identified flow cyt...

Tumor infiltrating immune cells (TIICs) interact with tumor to influence development and progression. However, how the interaction between melanoma TIICs affects invasion metastasis of in congenital melanocytic nevus (CMN) is largely unknown. We analyzed multiple samples including various regions different depths metastatic tissues from two patients identified differential gene expression profi...