Background: Macrophage polarization plays a critical role in determining the inflammatory states. Hepcidin is a key negative regulator of iron homeostasis and functions. Although hepcidin has been shown to affect ferroportin expression in macrophages, whether it affects macrophage polarization is still largely unknown. Objective: To address whether hepcidin ind...

patients afflicted by diabetes mellitus (dm) usually have more infections than those without dm. the course of the infections is also more complicated in this group of patients. one of the possible causes of increased infections prevalence is a deficiency in the immunity. besides some decreased cellular responses in vitro, no disturbances in adaptive immunity in diabetic patients have been desc...

background : the study was aimed to show the effect of molecular mechanism of aqueous garlic extract (age) on expression of ifnγ and inos genes in leishmania major . methods : leishmania major promastigotes (mrho/ir/75/er) were added to the in-vitro cultured j774 cell line, the cells were incubated for 72 hours. various concentrations of garlic extract (9.25, 18.5, 37, 74, 148 mg/ml) were added...

background: falciparum malaria is a severe health burden worldwide. antigen presenting cells are reported to be affected by erythrocytic stage of the parasite. malarial hemozoin (hz), a metabolite of malaria parasite, has adjuvant properties and may play a role in the induction of immune response against the parasite. objective: to determine the immunological impact of hemozoin on the capacity ...

macrophage activating syndrome (mas) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, still's disease, polyarteritis nodosa. it is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. a 27 yr. old female patient was admitted in shahid mostafa khomeini hospital (tehra...

objective(s) previous studies have demonstrated that the nitric oxide (no) dependent death of murine peritoneal macrophages activated in vitro with ifn-g and lps is mediated through apoptosis. in the present study, we investigated the synergistic effect of lps, ifn-g and iron on no production and apoptosis. materials and methods after determination of iron cytotoxicity, the peritoneal macrophag...

abstract  background: despite the long-standing association of macrophage migration inhibitory  factor (mif) with delayed-type hypersensitivity response, the potential role  of mif in chronic allograft nephropathy is unknown. the association between upregulation of mif expression, macrophage and t cell infiltration and the severity of  chronic allograft nephropathy suggests that mif may be an i...

The parasites of genus Leishmania are the causative agents of one of the most widespread and devastating diseases. According to follow-up data, these medications may provoke adverse drug reactions, drug resistance, relapse as well as financial burden. The mechanism of action of opioid drugs are primarily exerted via transmembrane G-protein coupled receptors. One of the potent synthetic immunomo...

objective(s) shark liver oil (slo) is an immunomodulator. macrophages play a key role in host defense against pathogens like fungi. candida albicans have mechanisms to escape immune system. we determined the effect of killed-candida on the in vitro viability of macrophages and the effect of slo on augmentation of this potency. materials and methods peritoneal macrophages were separated and cult...