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نتایج جستجو برای Microglial cells

تعداد نتایج: 908310  

Multiple sclerosis (MS) is the most common autoimmune disease, especially among young’s. Neuroinflammation results from inflammation in CNS and it may cause different disorders and diseases .It is also known as a detriment in multiple sclerosis. In fact, it causes problems and symptoms in MS. In MS the self-immune cells attack the myelin of neurons, it maybe the nerve in brain or spinal c...

Journal: :Folia neuropathologica 2005
Marcin Wojtera, Beata Sikorska, Tomasz Sobow, Paweł P Liberski,

Microglia are resident immune cells of the CNS. They are involved in the pathogenesis of diverse neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, prion diseases as well as multiple sclerosis, amyotrophic lateral sclerosis and AIDS dementia complex. It is widely accepted that microglia contribute to the neurodegeneration through a release of a variety of proinflammato...

Banafsheh Amiraslani, Farzaneh Sabouni, Habiballah Nazem, Mohammadsadegh Sabet, Shahsanam Abbasi,

Background: Neuroinflammation, as a major outcome of microglia activation, is an important factor for progression of neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. Microglial cells, as the first-line defense in the central nervous system, act as a source of neurotoxic factors such as nitric oxide (NO), a free radical which is involved in neuronal cell death. ...

Background: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and NLRP3 in microglia remains poorly understood. Objective: To investigate w...

Journal: :مجله علوم اعصاب شفای خاتم 0
sara abbassi student research committ...,

multiple sclerosis (ms) is the most common autoimmune disease, especially among young’s. neuroinflammation results from inflammation in cns and it may cause different disorders and diseases .it is also known as a detriment in multiple sclerosis. in fact, it causes problems and symptoms in ms. in ms the self-immune cells attack the myelin of neurons, it maybe the nerve in brain or spinal cord. d...

Journal: :PLoS ONE 2008
Sung-Min Ahn, Kyunghee Byun, Kun Cho, Jin Young Kim, Jong Shin Yoo, Deokhoon Kim, Sun Ha Paek, Seung U. Kim, Richard J. Simpson, Bonghee Lee,

Albumin, an abundant plasma protein with multifunctional properties, is mainly synthesized in the liver. Albumin has been implicated in Alzheimer's disease (AD) since it can bind to and transport amyloid beta (Abeta), the causative agent of AD; albumin is also a potent inhibitor of Abeta polymerization. Despite evidence of non-hepatic transcription of albumin in many tissues including kidney an...

Journal: :Free radical biology & medicine 2012
Rana Awada, Philippe Rondeau, Sandra Grès, Jean Sébastien Saulnier-Blache, Christian Lefebvre d'Hellencourt, Emmanuel Bourdon,

Oxidative stress occurs when antioxidant defenses are overwhelmed by oxygen-reactive species and can lead to cellular damage, as seen in several neurodegenerative disorders. Microglia are specialized cells in the central nervous system that act as the first and main form of active immune defense in the response to pathological events. Autotaxin (ATX) plays an important role in the modulation of...

2000
Bahram Ebrahimi, Timothy E Allsopp, John K Fazakerley, Gordon D Harkiss,

Maedi-Visna Virus (MVV) infection of the central nervous system (CNS) results in pathological changes, the mechanisms of which are poorly understood. MVV preferentially infects cell of the monocyte/macrophage lineage in vivo. The neuroparenchymal microglial cells are the resident tissue macrophages in the CNS and therefore likely targets for MVV infection. However, no information is currently a...

Journal: :The new microbiologica 2006
Marina Cinco, Rossana Domenis, Sandra Perticarari, Gianni Presani, Antonella Marangoni, Elisabetta Blasi,

Leptospires, the agents of leptospirosis, exert tropism for the central nervous system, in the course of mammal infection. We evaluated the interaction between murine microglial cells and strains of pathogenic L. interrogans leptospires and non-pathogenic L. biflexa leptospires, mainly by flow cytometric assays. In the absence of opsonic conditions microglia are capable of ingesting--even quite...

Journal: :Journal of immunology 2001
T Magnus, A Chan, O Grauer, K V Toyka, R Gold,

Apoptotic cell death is an established mechanism to terminate an inflammatory response in rodent or human brains. Microglia, as the resident phagocyte, is a strong candidate for the clearance of apoptotic lymphocytes. Apoptosis was induced in cultured autologous thymocytes and in myelin basic protein (MBP)-specific, encephalitogenic T cells from Lewis rats by the addition of 0.1 microg/ml methy...