نتایج جستجو برای Modification

تعداد نتایج: 86422  

2006
Tsunao SUZUKI,

The degradation of PVC at a processing temperature is mostly caused by its abnormal and unsta— ble molecular structures. It has been pointed out that its allyl chloride structures play a significant role as the abnormal and unstable structures. Inasmuch as the allyl chloride struc— tures are markedly more chemically active than the normal structure, the selective chemical treatments are applica...

2010
MURALI RAO,

Given a right continuous family Ft of complete o-fields and a bounded right continuous family Xt of random variables, we show in this paper that it is possible to modify the conditional expectations E(Xt\Ft) to be right continuous. When Xt=X, this reduces to a result of J. L. Doob. A famous result of Doob states that any martingale has a right continuous with left limits modification. This is a...

Journal: :Blood 2006
Li Song, Samita Bhattacharya, Ali A Yunus, Christopher D Lima, Christian Schindler,

Many proteins are known to undergo small ubiquitin-related modifier (SUMO) modification by an E1-, E2-, and E3-dependent ligation process. Recognition that protein inhibitor of activated signal transducers and activators of transcription (STATs) (PIAS) proteins are SUMO E3 ligases raised the possibility that STATs may also be regulated by SUMO modification. Consistent with this possibility, a S...

2013
Ian Cumpstey,

This review covers methods for modifying the structures of polysaccharides. The introduction of hydrophobic, acidic, basic, or other functionality into polysaccharide structures can alter the properties of materials based on these substances. The development of chemical methods to achieve this aim is an ongoing area of research that is expected to become more important as the emphasis on using ...

Journal: :Nature communications 2014
Christopher D Spicer, Benjamin G Davis,

Chemical modification of proteins is an important tool for probing natural systems, creating therapeutic conjugates and generating novel protein constructs. Site-selective reactions require exquisite control over both chemo- and regioselectivity, under ambient, aqueous conditions. There are now various methods for achieving selective modification of both natural and unnatural amino acids--each ...

2014
Diego Calderon,

M itochondria are integral to proper cell function, and mutations in its small genome (mtDNA) are associated with many diseases, along with the progression of normal aging [9]. While mtDNA has been extensively studied, not much is known about transcriptional variations of mitochondrial genes [3]. Recently, tRNA modifications have been the focus of intense study owing to their putative role in d...

Journal: :Molecular and cellular biology 2004
Susanne Steinert, Jerry W Shay, Woodring E Wright,

There is a discrepancy in telomere length as measured by signal intensity of telomere restriction fragments on gels and fluorescence in situ hybridization analysis. This difference has been ascribed to the X-region, a segment of subtelomeric DNA that is resistant to being cut by restriction enzymes. To explore the nature of this region, we analyzed the digestibility of an artificial seeded telo...

Journal: :Methods in molecular biology 2008
Erica B Schleifman, Joanna Y Chin, Peter M Glazer,

Gene targeting with DNA-binding molecules such as triplex-forming oligonucleotides or peptide nucleic acids can be utilized to direct mutagenesis or induce recombination site-specifically. In this chapter, several detailed protocols are described for the design and use of triplex-forming molecules to bind and mediate gene modification at specific chromosomal targets. Target site identification,...

2009
Itamar Francez,

This paper offers a new semantic theory of existentials (sentences of the form There be NPpivot XPcoda) in which pivots are (second order) predicates and codas are modifiers. The theory retains the analysis of pivots as denoting generalized quantifiers (Barwise and Cooper 1981; Keenan 1987), but departs from previous analyses in analyzing codas as contextual modifiers on a par with temporal/loc...

2012
Kevin A. Wilkinson, Filip Konopacki, Jeremy M. Henley,

Kainate receptors (KARs) are tetrameric glutamate-gated ion channels composed of combinations of the subunits GluK1-5. Depending on their precise localization and subunit composition, KARs can regulate neurotransmitter release, synaptic function and neuronal excitability. Because of these diverse roles, the regulated and precisely targeted trafficking of KARs is of crucial importance to neurona...

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