All-trans retinoic acid (tRA) is a potent differentiation agent that is effective therapy for acute promyelocytic leukemia (APL). However, 5% to 25% of patients develop retinoic acid syndrome, a potentially life-threatening complication in which the pathogenesis relates to adhesive alterations of APL cells. Therefore, we investigated the relationship between tRA-induced differentiation and the ...

BACKGROUND Biliary leaks have been treated with endoscopic management using different techniques with conflicting results. Furthermore the appropriate rescue therapy for refractory leaks has not been established. We evaluated the clinical effectiveness of initial endotherapy for postcholecystectomy biliary leaks using an homogenous approach (sphincterotomy + placement of a 10-French plastic ste...

INTRODUCTION Diagnosis of the mucopolysaccharidoses (MPSs) generally relies on an initial analysis of total glycosaminoglycan (GAG) excretion in urine. Often the dimethylmethylene blue dye-binding (DMB) assay is used, although false-negative results have been reported. We report a multiplexed diagnostic test with a high sensitivity for all MPSs and with the potential to identify patients with I...

MOTIVATION With the expansion of whole-genome studies, there is rapid evolution of genotyping platforms. This leads to practical issues such as upgrading of genotyping equipment which often results in research groups having data from different platforms for the same samples. While having more data can potentially yield more accurate copy-number estimates, combining such data is not straightforw...

Lattice models consisting of high-dimensional local degrees freedom without global particle-number conservation constitute an important problem class in the field strongly correlated quantum many-body systems. For instance, they are realized electron-phonon models, cavities, atom-molecule resonance or superconductors. In general, these systems elude a complete analytical treatment and need to b...

We study a team whose members choose a joint project and exert individual efforts to implement it. Members have private information about the productivities of alternative projects. We find conditions under which information fails to be shared and the most productive project fails to be selected. While the concealment of information can be efficient, the team’s incentive to conceal is inefficie...

in the past decades, we have witnessed a renascence of interest in vocabulary assessment (bachman, 2000). however, most researchers have focused on testing breadth rather than depth of vocabulary or receptive-productive dimensions of vocabulary knowledge (read, 2000; nation, 2001; wesche & paribahkt, 1996). the present research investigates the predicting variables of vocabulary knowledge acros...