نتایج جستجو برای Mycophenolic acid

تعداد نتایج: 505369  

Journal: :Applied and environmental microbiology 2000
I Schneweis, K Meyer, S Hörmansdorfer, J Bauer,

We examined 233 silage samples and found that molds were present in 206 samples with counts between 1 x 10(3) and 8.9 x 10(7) (mean, 4.7 x 10(6)) CFU/g. Mycophenolic acid, a metabolite of Penicillium roqueforti, was detected by liquid chromatography-mass spectrometry in 74 (32%) of these samples at levels ranging from 20 to 35,000 (mean, 1,400) microg/kg. This compound has well-known immunosupp...

Journal: :The Journal of antibiotics 1969
S Suzuki, T Kimura, K Ando, M Sawada, G Tamura,

n our laboratory in 4CS mice. (3) Mouse ascites hepatoma, MH134, was converted into ascitic form by Sato et al.*\ from a C3H/HeN mouse hapatoma induced after treatment with carbon tetrachloride by Andervont et al.5) It has been maintained in C3H/He mice with distinct strain specificity in tumor take in our laboratory. (4) Mouse ascites sarcoma, SR-C3H/He Th62, was originally induced with Schmid...

Journal: :Clinical chemistry 1997
A Griesmacher, G Weigel, G Seebacher, M M Müller,

Inosine 5'-monophosphate dehydrogenase (IMP-DH) activities were measured in human lymphocytes (exhibiting type I IMP-DH activity) and human lymphoblasts (exhibiting type II IMP-DH activity) in the presence of various amounts of mycophenolic acid (MPA) (0-20 mumol/L) and MPA glucuronide (MPAG) (0-200 mumol/L). Moreover, the influences of human serum albumin (HSA) and human plasma on the MPA- and...

Journal: :The Journal of antibiotics 1969
T Noto, M Sawada, K Ando, K Koyama,

Mycophenolic acid (MA) inhibits the growth of some pathogenic fungi such as Candida albicans, Cryptococcus neoformans and several species of Trichophyton at low concentrations in vitro. The antibiotic is more effectvie against fungi at slightly acidic pH than neutral pH. When administered to mice through the intraperitoneal, intramuscular and oral routes MA excreted toafewper cent in the urine....

Journal: :The Journal of antibiotics 1976
S Suzuki, S Takaku, T Mori,

One hundred and eight derivatives of mycophenolic acid (MA) have been prepared by modifications at the phenolic hydroxyl and/or carboxyl sites. None of these compounds was as effective as MA in suppressing cell growth of L-518Y cell in vitro, whereas several compounds with changes at both the hydroxyl and carboxyl groups were more effective than MA against Ehrlich solid carcinoma and L-1210 leu...

Journal: :Hypertension 2007
Bernard Lassègue, Kathy K Griendling,

Organ transplantation owes its spectacular development in recent decades to the introduction of immunosuppressive drugs capable of preventing allograft rejection. However, vasculopathy remains a major cause of long-term graft failure; thus, a better understanding of its mechanisms is required to improve tolerance. Because endothelial dysfunction is an early manifestation of vascular disorders, ...

Journal: :Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2013
Nazanin Honarbakhsh, Mohammad Reza Rouini, Mahboob Lesan-Pezeshki, Mohammad Reza Javadi, Iman Karimzadeh, Niayesh Mohebbi, Kheirollah Gholami,

OBJECTIVES To determine the mycophenolic acid pharmacokinetic profile early after transplant in Iranian kidney graft recipients. MATERIALS AND METHODS A cross-sectional study was performed during 6 months in 31 patients who recently had kidney transplant and received fixed doses of mycophenolate mofetil (2 g/d). The plasma levels of mycophenolic acid were determined by high performance liquid...

Journal: :The Biochemical journal 1969
T J Franklin, J M Cook,

1. Mycophenolic acid, an antibiotic of some antiquity that more recently has been found to have marked activity against a range of tumours in mice and rats, strongly inhibits DNA synthesis in the L strain of fibroblasts in vitro. 2. The extent of the inhibition of DNA synthesis is markedly increased by preincubation of the cells with mycophenolic acid before the addition of [(14)C]thymidine. 3....

Journal: :Acta virologica 2014
A Panattoni, A Luvisi, S Fuselli, F D Andrea, F Giorgelli, L Guazzelli, G Catelani, E Triolo,

KEYWORDS antiviral agents; chemotherapy; polyamidoamine; multivalency.

Journal: :Clinical chemistry 2000
O Millan, F Oppenheimer, M Brunet, J Vilardell, I Rojo, J Vives, J Martorell,

BACKGROUND Mycophenolic acid (MPA), a metabolite of mycophenolate mofetil (MMF), is an immunosuppressive agent that inhibits inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the ex novo synthesis of GTP. We measured IMPDH activity in peripheral blood mononuclear cells (PBMCs) from MMF-treated patients to evaluate the efficacy of MMF in individual patients. METHODS IMPDH activity w...

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