1791 Metabolic Effects of Cyclic 9-f3-D-Arabino furanosyladenine 3' , 5'-Monophosphate in L1210 Cells. Robert G. Hughes, Jr., and A. P. Kimball. 1795 Experimental Antitumor Activity and Pre clinical Toxicology of Mycophenolic Acid. Martin J. Sweeney, Koert Gerzon, Paul N. Harris, Richard E. Holmes, Gerald A . Poore, and Robert H. Williams. 1803 Metabolism and Biochemistry of Mycophenolic Acid. ...

Mycophenolic acid is a secondary extracellular metabolite of Penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. The aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by Penicillium brevi-compactum ATCC16024 was investigated. Batch submerged fer...

Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...

Pandemi COVID-19 memacu peneliti menginvestigasi beberapa senyawa potensial yang dapat menghambat SARS-CoV-2. Tujuan dari penelitian ini adalah mengevaluasi menggunakan pendekatan molecular docking untuk domain makro SARS-CoV-2 (PDB: 7CZ4). Evaluasi dilakukan berdasarkan skor AutoDock Vina. Konformasi terbaik kompleks reseptor ligan diindikasikan oleh afinitas tertinggi atau energi bebas Gibbs’...

In vitro and in vivo studies have shown that building-associated Penicillium spores and spore extracts can induce significant inflammatory responses in lung cells and animal models of lung disease. However, because spores and spore extracts comprise mixtures of bioactive constituents often including toxins, it is impossible to resolve which constituent mediates inflammatory responses. This stud...

background: the pathogenesis of many diseases is correlated to irregularity in vascular endothelial growth factor (vegf) expression. results from several association studies show that variation in the level of vegf expression is related to polymorphic sequences within the vegf gene. additionally, there are many studies showing that some gene polymorphisms significantly influence the pharmacokin...