نتایج جستجو برای: NF-κB
تعداد نتایج: 50648 فیلتر نتایج به سال:
سرطان پستان شایعترین نوع سرطان در زنان در سراسر جهان میباشد و استروژنها و گیرندههای استروژنی نقش مهم در اتیولوژی این نوع سرطان دارند. شیمیدرمانی، پرتودرمانی، جراحی و هورموندرمانی درمانهای رایج سرطان پستان محسوب می شوند. مشکل عمده درمانهای فعلی، عوارض جانبی متعدد از جمله آسیب به سلولهای سالم بدن، مقاومت به دارو و عود مجدد بیماری است. بنابراین دستیابی به راهکارهای درمانی جدید با سمیت و...
Background & objectives: Nuclear Factor kappa B (NF-κB), a master switch transcription factor, plays a critical role in the progression and development of hyperglycemia-induced microangiopathy. Hyperglycemia activates NF-κB, and subsequently increases pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β leading to development of inflammation. Some new studies have revealed the involvement o...
interleukin (il)-25, a cytokine of il-17 family, can activate p38 mitogen-activated protein kinases(mapk) and nuclear factor(nf)-κb pathways to propagate th2 responses. the allergic rhinitis mouse model was established by stimulating balb/c mouse with ovalbumin (ova). then we detected expression of il-25 and downstream p38mapk and nf-κb. the expression of il-25, p38mapk and nf-κb were detected ...
Background: Unit of p65 is one of the subunits of NF-κB and its phosphorylation by stress oxidative causes activation of NF-κB. The aim of present study was to investigate the effects of adenosine injection after brain ischemia reperfusion injury on gene expression of NF-κB /p65 and Reactive Oxygen Species (ROS) in hippocampus tissue of male wistar rats. Methods: 40 male wistar rats were rando...
Objective(s): To elucidate the effects and potential mechanisms of hypericin-photodynamic therapy (HYP-PDT) for treating the human rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) MH7A cell-line. Materials and Methods: MH7A cells were subjected to HYP-PDT intervention and apoptosis was evaluated via MTT, nuclear staining, and flowcytometry analyses. Intracellular reactive oxygen spec...
Introduction: Leukemia is considered one of the main causes of death, and current chemotherapeutic agents are unable to provide optimal responses due to chemo-resistance. Therefore, there is a constant need for new drugs. Cyclooxygenase- 2 (COX-2) inhibitors can be helpful by reducing the necessary dose of routine chemotherapeutic drugs. Herein, we evaluated the cytotoxicity activity as well...
Background and objectives: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibition results in an increase in apoptosis. It has been demonstrated that NF-κB subunit p65 phosphorylation at the IκB kinase phosphorylation site serine 536 (Ser536) is essential for the NF-κB nuclear translocation and activation. Therefore, NF-κB can be downregulated by suppressing its phosph...
Objective(s): High-glucose (HG) stress, a mimic of diabetes mellitus (DM) in culture cells, alters expression of a large number of genes including Wnt and NF-κB signaling-related genes; however, the role of Wnt signaling during HG-mediated fibroblast damage and the relationship between Wnt and NF-κB signaling have not been understood. In this study, we aimed to investigate the ffects of Wnt sig...
التهاب یکی از واکنشهای دفاعی بدن در برابر میکروارگانیسمها و عوامل حساسیتزا است. مسیر NF-Κb (Nuclear factor kappa-light-chain-enhancer of activated B cells) یک جزء ضروری از پاسخهای التهابی دخیل در تعدادی از بیماریهای دستگاه تنفسی مانند آسم و بیماری انسداد مزمن ریوی (COPD) است. در طب سنتی، گیاه Eucalyptus globulus Labill. از تیره Myrtaceae به شکل استنشاقی برای بیماریهای عفونی و التهابی دستگ...
Objectives: Epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells (RTECs) is a pathogenic factor for interstitial fibrosis (RIF). Interleukin-33 (IL-33) related to the occurrence and development RIF, but underlying mechanism remains unclear. Here, we investigated whether IL-33 mediates EMT RTECs by activating NF-κB/Twist1 signalling pathway. Methods: In vivo, RIF animal mode...
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