نتایج جستجو برای: NQO1
تعداد نتایج: 1144 فیلتر نتایج به سال:
NAD(P)H:quinone oxidoreductase 1(-/-) (NQO1(-/-)), NQO1(+/-) along with NRH:quinone oxidoreductase 2(-/-) (NQO2(-/-)), and wild-type (WT) mice were exposed to five once weekly doses of mitomycin C. The mice were euthanized 15 weeks after the first dose. Blood cell counts and histologic analyses were done. WT and NQO2(-/-) mice showed hypocellularity and a significant increase in adipocytes in b...
Protein degradation is an essential and highly regulated process. The proteasomal degradation of the tumor suppressors p53 and p73 is regulated by both polyubiquitination and by an ubiquitin-independent process. Here, we show that this ubiquitin-independent process is mediated by the 20S proteasomes and is regulated by NQO1. NQO1 physically interacts with p53 and p73 in an NADH-dependent manner...
BACKGROUND AND OBJECTIVES We examined common polymorphisms in the genes for glutathione S-transferase (GST), cytochrome P450 (CYP), quinone oxoreductase (NQO1), methylene tetrahydrofolate reductase (MTHFR), and thymidylate synthetase (TYMS) and the role of gender associated with the susceptibility to de novo acute leukemia (AL). DESIGN AND METHODS We conducted a case-control study analyzing t...
Mucous cell metaplasia (MCM) and neutrophil-predominant airway inflammation are pathological features of chronic inflammatory airway diseases. A signature feature of MCM is increased expression of a major respiratory tract mucin, MUC5AC. Neutrophil elastase (NE) upregulates MUC5AC in primary airway epithelial cells by generating reactive oxygen species, and this response is due in part to upreg...
چکید ه سابقه و هدف بسیاری از مطالعهها ثابت کردهاند که پلیمورفیسم ژن NQO1 ، باعث افزایش خطر ابتلا به لوسمی میلوئیدی حاد میشود. هدف از این مطالعه، ارزیابی میزان شیوع پلیمورفیسمهای C465T و NQO1 C609T در ایران و بررسی نقش این پلیمورفیسمها در افزایش خطر ابتلا به لوسمی میلوئیدی حاد بود. مواد و روشها مطالعه انجام شده از نوع مورد ـ شاهدی بود. با استفاده از روش PCR-RFLP ، به صورت تصاد...
Lung adenocarcinoma has replaced squamous cell lung carcinoma as the most frequent histological subtype in lung cancers. However, genetic factors that affect cancer susceptibility are much less understood in adenocarcinoma than in squamous cell carcinoma. In this study, polymorphisms in five genes involved in the metabolism of carcinogens or in the repair of damaged DNA in lung cells, NQO1-Pro1...
چکید ه سابقه و هدف سلولهای بنیادی مزانشیمی( MSCs ) به علت خصوصیات منحصر به فرد، سلولهایی ایده آل در زمینه های سلول درمانی و ژن درمانی میباشند. اما بقای کم آنها پس از پیوند، استفاده از آن ها را محدود کرده است. هدف این مطالعه، بررسی بیان ژنهای حفاظت سلولی شامل NQO1 ، TXNRD1 ، HO-1 ، GCLC پس از افزایش بیان Nrf2 در سلولهای بنیادی مزانشیمی بود. مواد و روشها در این مطالعه ت...
Amaç: Bu çalışmada da eşzamanlı kemoradyoterapi ile tedavi edilen evre III küçük hücreli dışı akciğer kanseri (KHDAK)’li hastalarda NQO1’in prediktif ve prognostik öneminin tespiti amaçlandı. Gereç Yöntemler: çalışmaya cisplatin+dosetaksel kemoradyoterapisi 64 KHDAK’li olgu dahil edildi. Hastaların patoloji preparatlarında NQO1 immünohistokimyasal (İHK) boyama yapılarak negatif pozitiflik açısı...
PURPOSE NRH:quinone oxidoreductase 2 (NQO2) is a homologue of NAD(P)H:quinone oxidoreductase 1 (NQO1). Despite 54% homology with human NQO1, NQO2 has little endogenous enzymatic activity. However, NQO2 has potential as a therapeutic target because the addition of the nonbiogenic electron donor dihydronicotinamide riboside (NRH) selectively potentiates the bioactivation of the alkylating agent t...
Glutathione S-transferases (GSTs), superoxide dismutase 2 (SOD2) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are anti-oxidant enzyme genes. Polymorphisms of GSTs, SOD2 and NQO1 have been reported to influence individual susceptibility to various diseases. In an earlier study, we obtained preliminary findings that a subset of glutathione S-transferase T1 (GSTT1)-wt patients with varicocele may e...
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