BACKGROUND Osteoporosis poses a significant public health issue. It is a skeletal disorder characterized by compromised bone strength that predisposes to increased risk of fracture. There is a direct relationship between the lack of estrogen after menopause and the development of osteoporosis. About 33% of women over 50 will experience bone fractures as a result of osteoporosis. Nigella Sativa ...

Metronidazole (MTZ) was the most widely accepted treatment for Blastocystis hominis (B. hominis) with high treatment failure rate, resistance and potential mutagenic and carcinogenic effects so there is urgent need to find out new, effective and safe treatment against B. hominis. The present research aimed to evaluate the therapeutic effect of the aqueous extract of Nigella sativa (NS) at diffe...

background: in this study, the protective effect of thymoquinone (tq) and nigella sativa seeds oil (nso) was evaluated against oxidative damages induced by ethanol in rats. methods: animals were treated with ethanol 40% daily by gavages once a day for 4 weeks. nso and tq were injected intraperitoneal once a day for 4 weeks. the histopathological examination of liver, kidney, brain and heart was...

objective: neuroimmune factors contribute on the pathogenesis of sickness behaviors. nigella sativa (ns) has anti-inflammatory, anti-anxiety and anti-depressive effects. in the present study, the effect of ns hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (lps) was investigated. materials and methods: the rats were divided into five groups (n=10 in each): (1) control...

nigella sativa is the miraculous plant having a lot of nutritional and medicinal benefits, and attracts large number of nutrition and pharmacological researchers. n. sativa seed composition shows that it is the blessing of nature and it contains and many bioactive compounds like thymoquinone, α-hederin, alkaloids, flavonoids, antioxidants, fatty acids many other compounds that have positive eff...

Our previous studies have demonstrated the relaxant, anticholinergic (functional antagonism), antihistaminic, and inhibitory effect of calcium channels of Nigella sativa on guinea pig tracheal chains. To investigate the other mechanism responsible for the relaxant effect of this plant, the stimulatory effect of Nigella sativa on ß 2 -adrenergic receptors in tracheal chains of the guinea pig was...

A recent study in 2019-2020 assessed the productivity, quality of fatty and essential oils, mineral composition eight nigella genotypes at Federal State Budget Scientific Institution (FSBSI), Research Institute Agriculture Crimea, Simferopol, Russia. Of genotypes, two cultivars originated from Russia (Nigella sativa cv. ‘Krymchanka,’ Nigella damascena ‘Yalita’), one each six European-Asian coun...

objectives: nigella sativa (n. sativa) is an amazing herb which is used in traditional medicine for a wide range of illnesses including bronchial asthma, dysentery, gastrointestinal problems, as well as beneficial effect on blood lipids, lowering blood pressure, serum cholesterol, and triglycerides level. this study aimed to determine the toxic effect of n. sativa powder on the kidney function ...

gastrointestinal (gi) diseases affect a large number of people all over the world. uncontrolled acid secretion and occurrence of gastric ulcers are common disorders of gi tract which pose serious problems to human health. many synthetic drugs have been used to treat gi disorders but a definite cure has not been discovered so far and the available medications cause several side effects. nigella ...

objective: the possible toxicity of drugs in pregnancy should be tested before their use in pregnant patients. in the present study, we aimed to evaluate the safety of phytovagex, a pessary formulation of nigella sativa (n. sativa), which is already in clinical use for vaginal fungal infection. materials and methods: the pregnant rats were treated intravaginal with physiological saline (vehicle...