Nigella sativa, an established historical and religion-based remedy for a wide range of health problems, is a herbal medicine known to have antioxidant and neuroprotective effects. This present study investigated the effect of Nigella sativa oil (NSO) administration on the spatial memory performance (SMP) of male adult rats using eight-arm radial arm maze (RAM). Twelve Sprague Dawley rats (7-9 ...

objective: oxidative stress plays an important role in the etiology of diabetic complications. diabetes impairs hippocampus neurogenesis, synaptic plasticity, and learning. the aim of this study was to investigate the effects of hydroalcoholic extract of nigella sativa seed on oxidative stress in stz-induced diabetic rats' hippocampus. materials and methods: diabetes induced by 60 mg/kg st...

Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(β-d-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3-6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(β-d-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation...

in order to evaluation the effect of nigella sativa supplementation on performance, immune response and some of blood parameters, a total of 192 one day old ross 308 broilers were used in a completely randomize design with four treatments, four replicates and 12 observations in each replicate. treatments included the increasing levels of zero (control), 0.4, 0.8 and 1.2 percent nigella sativa. ...

in the previous studies the relaxant, anti-cholinergic (functional antagonism) and anti-histaminic effects of nigella sativa have been demonstrated on guinea pig tracheal chains. to elucidate the main substance responsible for the relaxant effect of this plant, the effect of thymoquinone, one of the main constituent of nigella sativa was examined in this study. the bronchodilatory effects of th...

Background and objectives: Nigella sativa is a delicate floral vegetable belonging to Ranunculaceae family. Thymoquinone (TQ) is the dominant active component in Nigella sativa seed oil which has a variety of pharmacological properties such as antioxidant, anticancer, anti-inflammatory and analgesic activities. However, TQ is a quinone derivative, which may le...

Nigella sativa, known as black seed, has analgesic, anti-inflammatory, antioxidant and anticancer effects. It has been shown to reduce the development of kidney failure when given prior to the use of nephrotoxic drugs particularly due to its antioxidant action. However, as far as the authors could ascertain, there is no human study in literature showing these effects. Here we present a case of ...

background: the task force on plants for fertility regulation in men continued with its program to identify novel prototypes in plants alleged to have fertility regulating properties. nigella sativa   objective: to evaluated the role of alcoholic extract of nigella sativa on fertility potential, pituitary-testicular axis hormones and testosterone in male rats.   materials and methods: 24 male r...