We have concerned ourselves at the gastroenterology unit of the VU University Medical Center with drug repositioning since 2001. Generic therapy, often successfully used off-label in daily practice and well described in literature in large observational studies, should be further developed for safe and economically viable use. To prevent off-label use legislative authoritiesshouldstimulate re-r...

in descriptive statistics, there are two computational algorithms for determining the variance s2, of a set of observations : algorithm 1: s2= - , algorithm 2: s2= , where . it is interesting to discuss, which of the above formulas is numerically more trustworthy in machine numbers sets. i this paper, based on total effect of rounding error, we prove that the second algorithm is better than ...

in reinforced concrete design, there are situations where transfer of shear across a specific plane needs to be considered. examples of such situation include corbels, bearing shoes, ledger beam bearing, and a host of connection between precast concrete elements. in this study, the shear transfer behavior of reinforced concrete is investigated experimentally by conducting test on 6 precracked p...

in the open-pit mining, one of the first decisions that must be made in production planning stage, after completing the design of final pit limits, is determining of the processing plant cut-off grade. since this grade has an essential effect on operations, choosing the optimum cut-off grade is of considerable importance. different goals may be used for determining optimum cut-off grade. one of...

The main objective of this article is to optimize the walking pattern of a 2D humanoid robot with heel-off and toe-off motions in order to minimize the energy consumption and maximize the stability margin. To this end, at first, a gait planning method is introduced based on the ankle and hip joint position trajectories. Then, using these trajectories and the inverse kinematics, the position tra...

despite the reduction of mortality rate in the past years, coronary artery diseases (cads) are the main reason of death in the world. many factors including changes in nurses and medical staffs, numbers of beds influence the mortality rate of patients admitted in holidays and night time. the objectives of this study were to clarify the association between mortality rate and off-hours and holida...

one of the most common complications of operation and anesthesia is shivering. the purpose of this study was to compare the effectiveness of ondanseton and meperedine in preventing shivering after off-pump coronary artery bypass graft (opcab). in this double-blind randomized clinical trial, the sample consisted of 90 patients, who were candidates of cabg under general anesthesia. these patients...

background: to extract utility values of diabetic retinopathy on a perfect health and perfect vision scales for iranians with both types diabetes. methods: in this investigation, 150 untreated patients with diabetic retinopathy consecutively were examined and interviewed in farabi eye hospital, tehran, iran, a tertiary referral center in the iranian health care system. utility values based on p...