Ascorbic acid, β-glycerophosphate, and dexamethasone have been used in osteogenesis differentiation medium for in vitro cell culture, nothing is known for delivering these three bioactive compounds in vivo. In this study, we synthesized a novel bioactive scaffold by combining these three compounds with a lysine diisocyanate-based polyurethane. These bioactive compounds were released from the sc...

The macro-pore sizes of porous scaffold play a key role for regulating ectopic osteogenesis and angiogenesis but many researches ignored the influence of interconnection between macro-pores with different sizes. In order to accurately reveal the relationship between ectopic osteogenesis and macro-pore sizes in dorsal muscle and abdominal cavities of dogs, hydroxyapatite (HA) scaffolds with thre...

Osteogenesis imperfecta is a heritable disorder of bone formation resulting in low bone mass and a propensity to fracture. It exhibits a broad range of clinical severity, ranging from multiple fracturing in utero and perinatal death to normal adult stature and a low fracture incidence. The disorder is currently classified into seven types based on differences in clinical presentation and bone a...

conclusions callus distraction is an effective and reliable method for lengthening short phalangeal, metacarpal, and metatarsal bones. it also preserves periosteal tissue. our distractor is reliable, cheap, lightweight, user friendly, and highly effective for callotasis. background this study was performed to evaluate the results of finger lengthening following traumatic amputation or congenita...

distraction osteogenesis (do), firstly introduced to the medical world by russian scientist ilizarov for long bone lenghtening in orthopedics can be considered as an appropriate substitute in the treatment of maxillofacial deformities. natural events occuring during the repair of a fractured bone segment not only lead to the desired bone length but also prevent from the undesired disadvantages ...

Objectives: Osteopenia is frequent in HIV-infected patients treated with antiretroviral therapy (ART) and has been linked to increased osteoclastogenesis. Little known about the effects of ART on osteogenesis. Design: We investigated effect human mesenchymal stem cells (hMSC) osteoblasts Darunavir Dolutegravir, most highly used as anchor drugs within a three-drug regimen, Atazanavir, which was ...

OBJECTIVE To characterize the fracture pattern and the clinical history at the time of diagnosis of osteogenesis imperfecta. METHODS In this retrospective study, all patients with osteogenesis imperfecta, of both genders, aged 0-18 years, who were treated between 2002 and 2014 were included. Medical records were assessed to collect clinical data, including the presence of blue sclerae, dentin...

OBJECTIVES To conduct a systematic review of epidemiological literature to determine the incidence of bisphosphonate related osteonecrosis of the jaw occurring either spontaneously or after dental surgery, in children and adolescents diagnosed with osteogenesis imperfecta. MATERIAL AND METHODS MEDLINE, HMIC and EMBASE were used to search for English-language articles published from 1946 - 201...

The aim of this study was to evaluate the synergistic effect of platelet-rich plasma (PRP) and recombinant human bone morphogenic protein (BMP)-2 on accelerated osteogenesis of hydroxyapatite/β-tricalcium phosphate mixture and biphasic calcium phosphate (BCP) in mastoid obliteration. To the best of our knowledge, there have been no studies reporting the enhancing effects of BCP, combined with B...

MicroRNAs (miRNAs) are small endogenous noncoding RNAs that play an instrumental role in post-transcriptional modulation of gene expression. Genes related to osteogenesis (i.e., RUNX2, COL1A1 and OSX) is important in controlling the differentiation of mesenchymal stem cells (MSCs) to bone tissues. The regulated expression level of miRNAs is critically important for the differentiation of MSCs t...