ZnO NPs (zinc oxide nanoparticles) has generated significant scientific interest as a novel antibacterial and anticancer agent. Since oxidative stress is a critical determinant of ZnO NPs-induced damage, it is necessary to characterize their underlying mode of action. Different structural and physicochemical properties of ZnO NPs such as particle surface, size, shape, crystal structure, chemica...

introduction: neurodegenerative diseases are progressive disorders that could impair neuronal functions and structures. oxidative stress and mitochondrial dysfunction are involved in the etiology of neurodegenerative diseases such as alzheimer’s disease, parkinson’s disease and etc. gemfibrozil is used as a therapeutic drug for hyperlipidemia. it has been shown that gemfibrozil is neuroprotecti...

background and objective: a huge amount of investigational evidence support a role for oxidative stress as an intermediary of nerve cell dysfunction in parkinson’s disease (pd). polyphenols such as carvacrol have been indicated to prevent neuronal deterioration caused by increased oxidative load, thus, this study evaluated whether carvacrol administration would attenuate behavioral abnormalitie...

Staphylococci are a versatile genus of bacteria that are capable of causing acute and chronic infections in diverse host species. The success of staphylococci as pathogens is due in part to their ability to mitigate endogenous and exogenous oxidative and nitrosative stress. Endogenous oxidative stress is a consequence of life in an aerobic environment; whereas, exogenous oxidative and nitrosati...

objective(s): quinolinic acid (qa)-mediated excitotoxicity has been widely used as a model for studying neurodegenerative disorders. recent studies suggested that saffron (crocus sativus) or its active metabolite, i.e. safranal, exerts pharmacological actions on central nervous system including anxiolytic, anticonvulsant, and neuroprotective properties. the present study aimed to investigate th...

objective(s):the aim of this study was to evaluate the oxidative status and dna integrity in testes of wistar rat offspring exposed to omega-9 monounsaturated (mufa) at different times of late organogenesis. materials and methods:sixty female rats were divided into six groups of 10 animals. the first group served as control and received the drug vehicle, olive oil (1 ml/kg/day). the second, thi...

objective(s): in the current study antioxidant capacities of five different extracts of artemisia ciniformis aerial parts were evaluated by cell-free methods. then seven fractions of the potent extract were selected and their antioxidant capacity was assayed by cell free and cell based methods. materials andmethods: antioxidant ability was measured using the: 2, 2-diphenyl-1-picrylhydrazyl (dpp...

objective(s):multiple sclerosis (ms) is a demyelinating disease. the prevalence of ms is highest where environmental supplies of vitamin d are low. cognitive deficits have been observed in patients with ms. oxidative damage may contribute to the formation of ms lesions. considering the involvement of hippocampus in ms, an attempt is made in this study to investigate the effects of vitamin d3 on...

background: this study aims to investigate the effect of antioxidants supplement on clinical outcomes and antioxidant parameters in rheumatoid arthritis (ra). methods: the pre‑post study was conducted on 40 female patients with ra in 12 weeks that taken daily one “selenplus” capsule contained 50 μg selenium, 8 mg zinc, 400 μg vitamin a, 125 mg vitamin c, and 40 mg vitamin e. about 5 ml venous b...