Background Pyruvate carboxylase (PC) is a key enzyme for gluconeogenesis. PC deficiency (PCD) an extremely rare autosomal recessive metabolic disease and divided into three types. Type B PCD clinically featured by lactic acidosis, hyperammonemia, hypercitrullinemia, hypotonia, abnormal movement, seizures. Case presentation Here, we report the first case of type in China, presenting with intract...

Cadmium (Cd) is an environmental pollutant with high toxicity to animals and plants. It has been established that the glutathione (GSH)-dependent phytochelatin (PC) synthesis pathway is one of the most important mechanisms contributing to Cd accumulation and tolerance in plants. However, the transcription factors involved in regulating GSH-dependent PC synthesis pathway remain largely unknown. ...

OBJECTIVE STAT3 plays a vital role in inducing and maintaining a pro-carcinogenic inflammatory microenvironment and is reported to be a critical mediator of the oncogenic effects of EGFR mutations. STAT3 activation is mediated through JAK family kinases. We investigated the effect of the JAK1/2 inhibitor AZD1480 on lung tumors induced by an activating EGFR mutation. MATERIALS AND METHODS Thre...

BACKGROUND Pancreatic cancer (PC) surveillance is currently offered to individuals with a genetic predisposition to PC, but routinely used radiological screening modalities are not entirely reliable in detecting early-stage PC or its precursor lesions. We recently identified a discriminating PC biomarker signature in a sporadic patient cohort. In this study, we investigated if protein profiling...

The study was undertaken to investigate the features and clinical implications of hepatitis B virus (HBV) genotypes, basal core promoter (BCP) and precore (PC) mutations in hepatitis B-related acute-on-chronic liver failure (HB-ACLF). Samples from 75 patients with HB-ACLF and without pre-existing liver cirrhosis and 328 age-matched patients with chronic hepatitis B (CHB) were analyzed. HBV geno...

The manuscript, in which the CNIO Groups of Dr. Mariano Barbacid and Dr. Manuel Hidalgo, as well as the Group of Dr. Bruno Amati at the Italian FIRC Institute of Molecular Oncology (IFOM) have participated, describes a new strategy that allows a selective killing of cancer cells, given that the tumours present a particular feature. One of the main limitations of current cancer therapy is that t...

OBJECTIVE It is widely recognized that the diagnosis of parathyroid carcinoma (PC) is often difficult because of the overlap of characteristics between malignant and benign parathyroid tumors, especially at an early stage. Based on the identification of tumor suppressor gene HRPT2/CDC73 and its association with hereditary and sporadic PC, screening of gene mutations and detection of parafibromi...

The intelligent manufacturing of power systems has led to many challenges. cyber-physical system (CPS) was introduced solve the problem insufficient integration equipment and systems. It brings advantages, but also risks. In distribution network CPS, malicious attacks on PC-PLC communication can cause significant incidents affect safety. paper discusses two challenges, possible mutated virus mu...

The X-linked CBA/N defect in B cell function precludes an antibody response to phosphorylcholine (PC). Accordingly, (CBA/N X BALB/c)F1 male mice are unresponsive to PC and lack circulating immunoglobulin bearing the T15 idiotype characteristic of BALB/C anti-PC antibody. In contrast, (CBA/N X BALB/c)F1 female mice respond to PC and greater than 80% of the anti-PC antibody is T15+. No T-cell abn...