Introduction: Retinoid signaling has been argued to have favorable effects on Alzheimer's disease (AD). We studied the role of chronic intracerebroventricular (ICV) injection of all-trans retinoic acid (ATRA) on the amyloid-beta (Aβ) model of AD. Methods: Adult male rats weighing 260-330 g were divided into 12 groups of 8 each. Six groups of rats received ATRA (3nM, 30nM, 3μM, 0.3mM, 30...

Introduction: In this study, we investigated the role of N-Methyl-D-Aspartate (NMDA) receptors in the ventral hippocampus (VH) and their possible interactions with GABAA system on anxiety-like behaviors. Methods: We used an elevated-plus maze test (EPM) to assess anxiety-like behaviors and locomotor activity in male Wistar rats. Results: The results showed that intra-VH infusions of diffe...

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology Pharmacology (MP08)1 Sep 2021MP08-01 BRAIN α7 NICOTINIC ACETYLCHOLINE RECEPTORS ARE INVOLVED IN SUPPRESSION OF THE RAT MICTURITION REFLEX VIA GABA Takahiro Shimizu, Yohei Suo Zou, Hideaki Ono, Yurika Hata, Masaki Yamamoto, Takaaki Aratake, Shogo Youichirou Higashi, Takashi Karashima, Masashi Honda, and Motoaki Saito Shimizu...

The journal retracts the following article: “Efficacy of Mesenchymal Stem Cell and Vitamin D in Treatment Diabetes Mellitus Induced a Rat Model: Pancreatic Tissues [...]

in the present study, we have investigated the effects of silymarine on depression and the possible role of serotonergic system in these effects. the rats were anesthetized intraperitoneally with ketamine hydrochloride and placed in a stoelting stereotaxic instrument. a stainless steel guide cannula (22-gauge) was implanted in the third ventricular region. the third ventricular region was infus...

in this study, the possible involvement of l-type voltage-operated calcium channels in the vasorelaxant effect of the flavonoid quercetin was investigated, using the isolated aortic rings from normal male rats. addition of quercetin (0.1 µm-1 mm) caused a significant dose-dependent relaxation of noradrenaline (na)- and kcl-preconstricted rings and nifedipine attenuated this response, especially...

the aim of the present study was stereological evaluation of testes of azoospermic animal model using busulfan in rat. three groups of male adult rats were used in this study. the first group was injected by single dose of busulfan (10 mg kg-1) and their testes were removed on day 35 post injection. the second group received double doses of busulfan with 21 days interval and their testes were r...

background: disruption of testicular function and arrest ofspermatogenesis are the consequence of cryptorchidism inresponse to elevated temperature. objectives:this investigationwas set to clarify the possible ghrelin efficacy in altering somesperm quality parameters upon experimentally-induced cryptorchidism.methods: thirty male adult rats were scheduled for thestudy and were divided into thre...

background & aim: diabetes mellitus is a chronic disease characterized by elevated blood glucose levels and disturbances in carbohydrate, fat and protein metabolism. the objective of the present investigation was to evaluate the therapeutic efficacy of morus alba leaves in an animal model of diabetes. martial & methods: 30 adult male wistar strain rats (200-250 g) were divided randomly...