background and objective: diabetes mellitus is common endocrine disease cause learning and memory impairment. this study was done to evaluate the effect of quercetin on learning and memory in stz-induced diabetic rats was investigated. methods: in this experimental study, 40 male wistar rats were randomly allocated into five groups: control, quercetin - treated control, diabetic and quercetin -...

background antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-i‎nduced oxidative stress in rat. objectives in this experimental study, 20 male rats were equally divided into 4 groups (5 rats each), and were treated by propofol (10 mg/kg/day, ip), or cisplatin (7 mg /kg/day, ip), or both. conclusions it is concluded that oxidative ‎damage is the mechanism o...

introduction: there is not much data on parasitic infections of laboratory animals that are kept in conventional conditions in iran. the present study was designed to investigate intestinal helminths infections in laboratory colonies of rats and mice. methods: droppings from 110 mice and 110 rats (each animal one dropping) belonging to experimental and breeding groups in four animal houses were...

objective(s) this study aimed to investigate and to compare the effects of nifedipine and amlodipine, dihydropyridine (dhp) calcium channel blockers (ccbs) on perfusion pressure of isolated perfused rat kidney. materials and methods following the establishment of renal perfusion with a constant baseline pressure of 85-95 mmhg, the renal vasculature was constricted by phenylephrine (pe) injectio...

background: danae racemosa is used medicinally and as a culinary spice. its constituents are stated to have antithrombotic, antihepatotoxic, antinociceptive and antioxidant. objective: enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. methods: wistar male rat (n=30) were allocated into three g...

information about the health risks that might be associated with lipstick consumption effects is scarce in the literature. the present work investigated the bioaccumulation of lead (pb) in brain of rats originated from lipstick sample. first, lead contents were determined in 12 different brands of lipsticks. lead was detected in all the studied samples. the average lead content in 14 lipsticks ...

epilepsy is one of the common disorders in human community. clinical observations have shown that epileptic patients have often difficulty in learning and memory. kindling is a laboratory model for studying epilepsy and its complications. this experiment was designed to study the effect of chemical kindling on schaffer collateral-ca1 pyramidal cell synaptic transmission using pentylenetetrazole...

background: gentamicin (gm) is used as antibiotic for gram-negative infections, but its administration is limited due to a side-effect of nephrotoxicity. it was attempted to investigate the effect of althaea officinalis flower extract (aofe) against nephrotoxicity induced by gm in male rats. methods: 30-year-old male wistar rats were divided into five groups. group 1 as a negative control group...

background : numerous epidemiologic studies have shown that esophagus cancer is more common in areas with grains containing mycotoxin such as fumonisin b1 (fb1). the aim of this research is to study the effect of long- and short-term of esophagus tissue to fb1 orally administered in animal model. materials and methods : forty-four female mice have been divided in two short- and long-term groups...

objective(s): we investigated the histopathological effects of metamizole sodium (ms) on the sciatic nerve.  materials and methods: this study was performed using 48 adult male wistar albino rats. ten groups were constituted with 6 rats in each group. ms injection into the sciatic nerve (group 1), ms injection into the muscle [group 3 (50 mg/kg, 0.4 ml) and group 5 (50 mg/kg, 0.8 ml)], ms injec...