The magnitude of tensile stress and tensile strain at an anastomosis site under physiological stress is an important factor for the success of anastomosis following suturing in peripheral nerve injury treatment. Sciatic nerves from fresh adult cadavers were used to create models of sciatic nerve injury. The denervated specimens underwent epineurial and perineurial suturing. The elastic modulus ...

objective: to assess the effect of combination of pulsed electromagnetic fields (pemf) with predatory stress on transected sciatic nerve regeneration in rats.  methods: in sham- operated group (sog) the nerve was manipulated and left intact. the 10-mm rat sciatic nerve gap was created in rats. in transected group (transected) nerve stumps were sutured to adjacent muscle and in vein graft group ...

Sciatic nerve injury and dysfunction is not an uncommon cause of lower extremity symptoms in a musculoskeletal practice. The sciatic nerve derives its nerve fibers from the L4, L5, S1, S2, and S3 nerve roots. The sciatic nerve arises from the lumbosacral plexus and is composed of two distinct trunks: the lateral (peroneal division) and the medial (tibial division). The peroneal and the tibial d...

Endometriosis is a common disease characterized by the presence of endometrial tissue outside the uterus, such as over, colon, nasal mucosa. Furthermore, it can affect sciatic nerve as a rare presentation causing cyclic sciatica, chronic pelvic pain, paresis, and paresthesia. Early diagnosis and treatment is very important to minimize the nerve damage caused by endometrial focus on sciatic nerv...

Background: Axotomy causes sensory neuronal loss. Reconnection of proximal and distal nerve ends by surgical repair improves neuronal survival. It is important to know the morphology of primary sensory neurons after the surgical repair of their peripheral processes. Methods: Animals (male Wistar rats) were exposed to models of sciatic nerve transection, direct epineurial suture repair of sciati...

CONTEXT Although herniation of a lumbosacral intervertebral disk is a major cause of sciatic distribution pain, relentlessly progressive symptoms or signs should alert one to the possibility of a tumor involving the nerve. OBJECTIVE To describe the clinical, neurophysiological, and histological features of a pathologically unique tumor involving the sciatic nerve. SETTING Tertiary referral ...

Following traumatic peripheral nerve injury reinnervation of denervated targets may be achieved by regeneration of injured axons and by collateral sprouting of neighbor undamaged axons. Experimental models commonly use sciatic nerve injuries to assess nerve regeneration and neuropathic pain, but behavioral tests for evaluating sensory recovery often disregard the pattern of hindpaw innervation....

Peripheral nerves are organ-like structures containing diverse cell types to optimize function. This interactive assembly includes mostly axon-associated Schwann cells, but also endothelial cells of supporting blood vessels, immune system-associated barrier-forming the perineurium surrounding and protecting nerve fascicles, connective tissue-resident within intra-fascicular endoneurium inter-fa...

Terminal hip flexion contributes to increased strain in peripheral nerves at the level of the hip joint. The effects of hip abduction and femoral version on sciatic nerve biomechanics are not well understood. A decrease in sciatic nerve strain will be observed during terminal hip flexion and hip abduction, independent of femoral version. Six un-embalmed human cadavers were utilized. Three Diffe...

Objective- Adipose tissue is an appropriate source for isolation of cells with stem-cell–like properties.  In the present long-term study, the effects of the omental adipose-derived nucleated cells (OADNCs) fraction were compared to those of the undifferentiated cultured bone marrow stromal cells (BMSCs) on sciatic nerve regeneration. Design- Experimental in vivo study. Animals- Fift...