objective(s): to investigate the effect of topical administration of alpha-lipoic acid into chitosan conduit on peripheral nerve regeneration using a rat sciatic nerve transection model. materials and methods: forty five wistar rats were divided into three experimental groups randomly. a 10-mm gap of sciatic nerve was bridged with a chitosan conduit following surgical preparation and anesthesia...

background: olfactory ensheathing glia (oeg) has been shown to have a neuroprotective effect after being transplanted in rats with spinal cord injury. this study was conducted to determine the possible beneficial results of olfactory mucosa transplantation (omt) which is a source of oeg on functional recovery and axonal regeneration after transection of the sciatic nerve. methods: in this study...

  Despite promising results observed using silicone rubber chamber, no previous comprehensive work was performed on behavior of the conduit. Present study aimed at further functional, histomorphometrical and immunohistochemical assessment of nerve regeneration in the same animal along a 10-mm rat sciatic nerve gap. Fifty- four male Wistar rats were divided into three experimental groups (n = 1...

background: many people suffer from nerve injury. the time consuming nature of the treatments makes the condition worse. therefore, finding a way to accelerate the process of nerve repair is very important. objective: to determine the effect of ultrasound on the acceleration of crushed peripheral nerve regeneration. methods: the experimental model included crushed rat’s sciatic nerve. 40 rats w...

Objective(s): The purpose of this study is to investigate the indication function of the calcium circulation-related factors on the damage to muscle strength and contraction function after nerve injury. The target factors include ryanodine receptor (RyR), inositol-1,4,5-triphosphate receptor (IP3R), phospholamban (PLN), cryptocalcitonin (CASQ), ATPase and troponin C (T...

objective: the aim of present study was to evaluate the effects of oral administration of gallic acid (ga) for 21 days alone and in combination with exercise on nerve conduction velocity and sensory and motor functions in rats with sciatic nerve crush. materials and methods: seventy adult male wistar rats (250-300 g) were divided randomly into 7 groups with 10 in each: 1) control (cont), 2) cru...

objective(s) the role of elaeagnus angustifolia fruit as an analgesic agent in acute pain has been proved earlier. in this study, the effects of aqueous extracts of three parts of this fruit (pericarp, medulla and seed) on chronic pain were investigated in mice. materials and methods a partial nerve injury was made using a tight ligature around the sciatic nerve, then doses (0.5, 1, 1.5 g/kg, i...

background: peripheral nerves may be damaged during an injury and its current standard treatment is using an autologous nerve. objectives: the purpose of this experimental study is to evaluate and compare the histological results of nerve regeneration after using the eggshell membrane (esm) guidance channel with autograft. materials and methods: thirty adult male rats were divided into three ex...

Objective(s): To investigate the effect of topical administration of alpha-lipoic acid into chitosan conduit on peripheral nerve regeneration using a rat sciatic nerve transection model. Materials and Methods: Forty five Wistar rats were divided into three experimental groups randomly. A 10-mm gap of sciatic nerve was bridged with a chitosan conduit following surgical preparation and anesthesia...

Sciatic nerve is the thickest nerve of the sacral plexus, which innervates many muscles and vast areas of the skin of the lower limb. It leaves the pelvis via the greater sciatic foramen, emerges into the gluteal region by passing under the piriformis muscle, and descends beneath the gluteus maximus to divide into its terminal branches: tibial and common peroneal nerve at the superior angle of ...