objective autosomal recessive congenital ichthyosis (arci) is a rare, heterogenous keratinization disorder of the skin, classically divided into two clinical subtypes, lamellar ichthyosis (li) and nonbullous congenital ichthyosi-formis erythroderma (ncie). lamellar ichtyosis is caused by mutations in the tgm1 gene that encodes transglutaminase 1 enzyme, which is critical for the assembly of the...

objective(s):  more than 1500 registered mutations in cystic fibrosis transmembrane regulator (cftr) gene are responsible for dysfunction of an ion channel protein and a wide spectrum of clinical manifestations in patients with cystic fibrosis (cf). this study was performed to investigate the frequency of a number of well-known cftr mutations in north eastern iranian cf patients. material and m...

it is difficult to distinguish between clinically significant slowly-growing, non-pigmented mycobacteria, notably to separate m. aviumand m. intracellulare from one another and from m. scrofulaceum strains. the purpose of this study was to evaluate the extent to which 16s rrna sequencing could be used to highlight the taxonomic relationships of the mycobacterial strains, which are difficult to ...

conclusions overall, results of present study were consistent with the data reported earlier base on 5’ ntr in iranian isolates and revealed genotype ir2 is major genotype in iranian hgv-positive patient. it means there are higher similarities between iranian and europe-usa in hgv ns3 gene. results nucleotide blast results emphasized that most similar sequences to ir ns3 sequences were those fr...

introduction: the major resistance mechanisms of pseudomonas aeruginosa to fluoroquinolones and carbapenems are associated with the mutations in the genes gyra and oprd encoding type ii topoisomerases (dna gyrase) and oprd porin, respectively. method: in this cross-sectional study, sixty five clinical samples were collected from patients hospitalized in al-zahra hospital of isfahan, iran. susce...

conclusions we concluded from the results that the frequency of emb-resistant m. tuberculosis cases in iran is lower than that of many other regions. the pcr-sscp technique can separate resistant isolates from sensitive isolates. the sequencing results of this study showed mutation in codons 309 and 299 of the embb gene. in none of the resistant isolates, mutation was observed in codon 306. fur...

charcot-marie-tooth (cmt) diseases represent a heterogeneous genetic disorder with more than 80 genes implicated, however sharing a similar phenotype. in recent years, advances in molecular genetics and molecular biology, and also the development of various animal models of cmt, have led to a better understanding. this knowledge represents a prerequisite for the development of future therapies ...

conclusions with the proper operation of wastewater the treatment plant and increasing the retention time, the removal efficiency of the detergents increased. in addition, according to the environmental standards for bod5, cod and the detergents, the results of the present study indicated that the outputs of these parameters from the sbr system were appropriate for agricultural irrigation. resu...

background: neosporosis is caused by an obligate intracellular parasitic protozoa neospora caninum which infect variety of hosts. ncsrs2 is an immuno-dominant antigen of n. caninum which is consi-dered as one of the most promising targets for a recombinant or dna vaccine against neosporosis. as no study has been carried out to identify the molecular structure of n. caninum in iran, as first ste...

background: leishmaniasis is a protozoan disease cause by leishmania genus. anthroponotic and zoono­tic cutaneous leishmaniasis are endemic in iran. the aim of this study was to identify the causative agent of cutaneous leishmaniasis by mini-exon gene in five regions of khuzestan province, southwest of iran. methods: from 2007 to 2008 in this cross-sectional study, cutaneous samples were collec...