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نتایج جستجو برای Spermatogonia

تعداد نتایج: 1463  
Journal: :Reproduction 2001
S Meachem, V von Schönfeldt, S Schlatt,

Interest in spermatogonia has grown in recent years as a result of exciting developments in stem cell research in general and the development of new research tools allowing the isolation, culture and transplantation of these cells. This review focuses on the methodological breakthroughs and highlights the recent findings that have substantially increased understanding of spermatogonial physiolo...

Journal: :Endocrinology 2012
Aurore Gely-Pernot, Mathilde Raverdeau, Catherine Célébi, Christine Dennefeld, Betty Feret, Muriel Klopfenstein, Shosei Yoshida, Norbert B Ghyselinck, Manuel Mark,

Vitamin A is instrumental to mammalian reproduction. Its metabolite, retinoic acid (RA), acts in a hormone-like manner through binding to and activating three nuclear receptor isotypes, RA receptor (RAR)α (RARA), RARβ, and RARγ (RARG). Here, we show that 1) RARG is expressed by A aligned (A(al)) spermatogonia, as well as during the transition from A(al) to A(1) spermatogonia, which is known to ...

A. Ozdal Gokdal, A. Yilmaz,

In this review, we aim to examine the effect of extrinsic and intrinsic factors on spermatogenesis process taking into account a complex signaling pathway. Primarily, it is suggested that retinoic acid (RA) has a vital function in spermatogenesis process and it is considered to be essential for completion of spermatogonia into mature spermatozoa. In the present review, the key effects of retino...

Journal: :Asian journal of andrology 2007
En-Zhong Li, De-Xue Li, Shi-Qing Zhang, Chang-Yong Wang, Xue-Ming Zhang, Jing-Yan Lu, Cui-Mi Duan, Xiang-Zhong Yang, Li-Xin Feng,

AIM To investigate whether estrogen stimulates the proliferation of spermatogonia or induces spermatogenesis in cryptorchid mice. METHODS Mice were surgically rendered cryptorchid, then treated with different doses of 17beta-estradiol (E2) s.c. once a day. Mice were killed at sexual maturity (45 days of age), and histological analysis and immunofluorescence were performed. Serum follicle stim...

2017
Longchang Xu, Yalan Lu, Deqiang Han, Rongyan Yao, Han Wang, Shunshun Zhong, Yanyun Luo, Ruiqin Han, Kai Li, Jun Fu, Shudong Zong, Shiying Miao, Wei Song, Linfang Wang,

Spermatogenesis, the process by which haploid sperm cells are produced from a diploid precursor cell, is essential for sexual reproduction. Here, we report that RING-finger protein 138 (Rnf138) is highly expressed in testes, especially in spermatogonia and spermatocytes. The role of Rnf138 in spermatogenesis was examined using a Rnf138-knockout mouse model. Rnf138 deficiency resulted in increas...

Journal: :Development 2016
Dawn L Lovelace, Zhen Gao, Kazadi Mutoji, Yuntao Charlie Song, Jianhua Ruan, Brian P Hermann,

Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout adulthood through balanced self-renewal and differentiation, yet the regulatory logic of these fate decisions is poorly understood. The transcription factors Sal-like 4 (SALL4) and promyelocytic leukemia zinc finger (PLZF; also known as ZBTB16) are known to be required for normal SSC function, but their targets are largely unk...

Journal: :Reproductive biology 2012
Agnieszka Kolasa, Kamila Misiakiewicz, Mariola Marchlewicz, Barbara Wiszniewska,

Spermatogenesis is a complex series of cellular changes leading to the formation of haploid male gametes (spermatozoa) and includes mitotic, meiotic and post-meiotic phases. Spermatogonial stem cells (SSCs) are essential for the continuous lifelong production of spermatozoa. Spermatogenesis is initiated when SSC is triggered to undergo mitosis that gives rise to progenitors, which further diffe...

2014
Kyung Hoon Lee, Ran Lee, Won Young Lee, Dong Hoon Kim, Hak Jae Chung, Jin Hoi Kim, Nam Hyung Kim, Suk Hwa Choi, Jae Hwan Kim, Hyuk Song, Qing-Yuan Sun,

BACKGROUND In vitro culture of spermatogonial stem cells (SSCs) is important for exploration of SSCs self-renewal, differentiation, and manipulation. There are several reports on rodent SSC cultures; however, data on SSC cultures in domestic animals are limited. To provide basic scientific information on canine SSC cultures, we report canine testes development, and the development of spermatogo...

2016
David Fleck, Nadine Mundt, Felicitas Bruentgens, Petra Geilenkirchen, Patricia A Machado, Thomas Veitinger, Sophie Veitinger, Susanne M Lipartowski, Corinna H Engelhardt, Marco Oldiges, Jennifer Spehr, Marc Spehr,

Spermatogenesis ranks among the most complex, yet least understood, developmental processes. The physiological principles that control male germ cell development in mammals are notoriously difficult to unravel, given the intricate anatomy and complex endo- and paracrinology of the testis. Accordingly, we lack a conceptual understanding of the basic signaling mechanisms within the testis, which ...

Journal: :The Journal of clinical investigation 1985
M C Cheng, J A Clements, A I Smith, S J Lolait, J W Funder,

In previous reports modest levels of beta-endorphin have been found by radioimmunoassay in rat testis, and localized by immunofluorescence to the interstitial cells. We have confirmed these previous reports and extended them by showing that the majority of testicular endorphins are acetylated forms, N-acetyl gamma-endorphin, N-acetyl alpha-endorphin, and N-acetyl beta-endorphin1-27. In addition...